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BAG6 and CDK5
Data Source:
BioGRID
(two hybrid)
BAG6
CDK5
Description
BAG cochaperone 6
cyclin dependent kinase 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Extracellular Exosome
BAT3 Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Perikaryon
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Molecular Function
Signaling Receptor Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Misfolded Protein Binding
Proteasome Binding
Ubiquitin-specific Protease Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Protein Kinase Binding
Acetylcholine Receptor Activator Activity
ErbB-3 Class Receptor Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Kidney Development
Immune Response-activating Cell Surface Receptor Signaling Pathway
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Synaptonemal Complex Assembly
Spermatogenesis
Brain Development
Proteasomal Protein Catabolic Process
Internal Peptidyl-lysine Acetylation
Natural Killer Cell Activation
Cell Differentiation
Lung Development
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Proteolysis
Regulation Of Embryonic Development
Protein Stabilization
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
ER-associated Misfolded Protein Catabolic Process
Tail-anchored Membrane Protein Insertion Into ER Membrane
Positive Regulation Of ERAD Pathway
Maintenance Of Unfolded Protein Involved In ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Protein Phosphorylation
Intracellular Protein Transport
Nucleocytoplasmic Transport
Mitochondrion Organization
Cell-matrix Adhesion
Chemical Synaptic Transmission
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Visual Learning
Response To Wounding
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Phosphorylation
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Corpus Callosum Development
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Cortical Actin Cytoskeleton Organization
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Positive Regulation Of Protein Binding
Receptor Catabolic Process
Positive Regulation Of Glial Cell Apoptotic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Serine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Autophosphorylation
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Synapse Pruning
Regulation Of Neurotransmitter Receptor Activity
Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Negative Regulation Of Neuron Death
Positive Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Localization To Plasma Membrane
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Factors involved in megakaryocyte development and platelet production
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Height (
28552196
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Schizophrenia (
23894747
)
Small cell lung carcinoma (
28604730
)
Smoking status (ever vs never smokers) (
30643258
)
Ulcerative colitis (
28067908
)
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
118 interacting genes:
ACVR1B
AMFR
AMTN
ANTKMT
ANXA7
APBB1IP
ARPC3
ATN1
ATXN2
B2M
C1QA
CD93
CDK16
CDK4
CDK5
CDKN1A
CDSN
CHN2
CILK1
CLU
CSNK2B
CSTF2
CTAG1A
CTAG1B
CTCFL
CTSB
CTSE
CTSL
CXCL8
CYSRT1
DMKN
DNAJB11
DPT
EDN1
EFEMP1
EFEMP2
ELP1
EP300
FAM9B
FAS
FKBP2
FZD4
GADD45A
GET4
GLRA2
GOLGA6L9
GSK3B
HSPA13
HSPA8
IGF2
IGFBP5
IMMT
IQCG
KLHL12
KPNA2
LBP
MAPK6
MEST
MTNR1A
MYDGF
NBL1
NCR3
NDUFA6
NDUFB11
NOMO1
NPY
NR1H2
PELP1
PIN1
PLA2G2A
PLK1
PLPP2
PLPPR3
POLR2J
PRKAR1B
PRMT2
PRNP
PRPF40A
PTH
PTN
PTPN12
RAB8A
RAC1
RCC1
RCN2
REG1B
RNF126
S100A4
SDC2
SEC61A1
SEC61B
SERPING1
SERPINH1
SERPINI2
SETDB1
SGTA
SMN1
SPP1
SRGN
STX5
TAC1
TDGF1
TENT5A
TFCP2
TK1
TOMM20
TP53
TP63
TTR
UBL4B
UBL7
UBQLN1
UBQLN2
UBQLN4
USP13
VAMP2
XRN1
ZFYVE9
81 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CCNI
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PRKN
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SPDYE4
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
Entrez ID
7917
1020
HPRD ID
00808
00449
Ensembl ID
ENSG00000204463
ENSG00000164885
Uniprot IDs
A0A1U9X7A6
P46379
A0A090N7W4
A0A0S2Z355
Q00535
PDB IDs
1WX9
2N9P
4DWF
4EEW
4WWR
4X86
6AU8
1H4L
1LFR
1UNG
1UNH
1UNL
3O0G
4AU8
Enriched GO Terms of Interacting Partners
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