RPS6KA3 and SMS

Data Source:
BioGRID (two hybrid)

		RPS6KA3	SMS
Description		ribosomal protein S6 kinase A3	spermine synthase
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol	Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity	Spermine Synthase Activity
	Biological Process	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Metabolism of polyamines
Drugs		Acetylsalicylic acid Fostamatinib	Spermine
Diseases		Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)	Snyder-Robinson syndrome
GWAS		Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1	5 interacting genes: EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3
Entrez ID		6197	6611
HPRD ID		02092	02115
Ensembl ID		ENSG00000177189	ENSG00000102172
Uniprot IDs		A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812	P52788
PDB IDs		4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L	3C6K 3C6M
Enriched GO Terms of Interacting Partners?
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