RPS6KA3 and SHANK1

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		RPS6KA3	SHANK1
Description		ribosomal protein S6 kinase A3	SH3 and multiple ankyrin repeat domains 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol	Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Dendritic Spine Postsynaptic Membrane Excitatory Synapse
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Protein C-terminus Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Acetylsalicylic acid Fostamatinib
Diseases		Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Refractive error ( 32231278)	Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1	19 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8
Entrez ID		6197	50944
HPRD ID		02092	05413
Ensembl ID		ENSG00000177189	ENSG00000161681
Uniprot IDs		A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812	H9KV90 Q9Y566
PDB IDs		4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L	6CPI
Enriched GO Terms of Interacting Partners?
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