RPS6KA3 and CTNND1

Data Source:
BioGRID (enzymatic study)

		RPS6KA3	CTNND1
Description		ribosomal protein S6 kinase A3	catenin delta 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Catenin Complex Lamellipodium Growth Cone Midbody Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity	Signaling Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding
	Biological Process	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Cell-cell Junction Assembly Brain Development Wnt Signaling Pathway Adherens Junction Organization Entry Of Bacterium Into Host Cell Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells
Drugs		Acetylsalicylic acid Fostamatinib
Diseases		Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Refractive error ( 32231278)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)
Interacting Genes		40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1	32 interacting genes: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBIN FER GRIK2 GSK3B JUP KCTD6 LCK MAPK1 MAPK3 MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RPS6KA3 SMURF1 SNCA SRC SUMO2 YWHAG ZBTB33
Entrez ID		6197	1500
HPRD ID		02092	03026
Ensembl ID		ENSG00000177189	ENSG00000198561
Uniprot IDs		A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812	O60716
PDB IDs		4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L	3L6X 3L6Y
Enriched GO Terms of Interacting Partners?
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