Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
DLG3 and ATP2B4
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
DLG3
ATP2B4
Description
discs large MAGUK scaffold protein 3
ATPase plasma membrane Ca2+ transporting 4
Image
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Plasma Membrane
Ionotropic Glutamate Receptor Complex
Basolateral Plasma Membrane
Cell Junction
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Membrane
Basolateral Plasma Membrane
Z Disc
T-tubule
Protein-containing Complex
Sperm Flagellum
Neuron Projection
Intracellular Membrane-bounded Organelle
Membrane Raft
Sperm Principal Piece
Glutamatergic Synapse
Integral Component Of Presynaptic Active Zone Membrane
Molecular Function
Protein Binding
Kinase Binding
Phosphatase Binding
Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism
Protein Binding
Calmodulin Binding
ATP Binding
Calcium Ion Transmembrane Transporter Activity
Sodium Channel Regulator Activity
ATPase-coupled Cation Transmembrane Transporter Activity
Protein Kinase Binding
PDZ Domain Binding
Protein Phosphatase 2B Binding
Nitric-oxide Synthase Inhibitor Activity
Metal Ion Binding
Calcium-dependent Protein Binding
Nitric-oxide Synthase Binding
Scaffold Protein Binding
Biological Process
MAPK Cascade
Negative Regulation Of Cell Population Proliferation
Embryo Development
Negative Regulation Of Phosphatase Activity
Receptor Clustering
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Protein Tyrosine Kinase Activity
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of NMDA Receptor Activity
Neural Retina Development
Regulation Of Transcription By RNA Polymerase II
Cellular Calcium Ion Homeostasis
Spermatogenesis
Negative Regulation Of Gene Expression
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Urinary Bladder Smooth Muscle Contraction
Negative Regulation Of Angiogenesis
Hippocampus Development
Flagellated Sperm Motility
Positive Regulation Of Peptidyl-serine Phosphorylation
Ion Transmembrane Transport
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Nitric Oxide Biosynthetic Process
Negative Regulation Of Nitric-oxide Synthase Activity
Regulation Of Cytosolic Calcium Ion Concentration
Response To Hydrostatic Pressure
Calcium Ion Transmembrane Transport
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Epinephrine Stimulus
Calcium Ion Transmembrane Import Into Cytosol
Calcium Ion Import Across Plasma Membrane
Negative Regulation Of The Force Of Heart Contraction
Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Transport Across Blood-brain Barrier
Negative Regulation Of Arginine Catabolic Process
Calcium Ion Export
Negative Regulation Of Peptidyl-cysteine S-nitrosylation
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Negative Regulation Of Citrulline Biosynthetic Process
Regulation Of Cardiac Conduction
Cellular Response To Acetylcholine
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases
Drugs
Halothane
Desflurane
Diseases
Non-syndromic X-linked mental retardation
GWAS
Mean platelet volume (
32888494
)
Breast size (
22747683
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Immature fraction of reticulocytes (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Malaria (
22895189
31844061
)
Mean corpuscular hemoglobin concentration (
23263863
32888494
28453575
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Monocyte count (
32888494
)
Obstructive sleep apnea (average oxygen saturation during sleep) (
26977737
)
Plateletcrit (
32888494
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
48 interacting genes:
ABCA1
ADGRL1
APC
ATP2B4
CACNG2
CALM1
CNKSR2
CRIPT
DHRS11
DLG1
DLG4
DLGAP1
DLGAP2
DLGAP3
DLGAP4
EIF4H
ERBB4
EXOC4
EXOC7
GDA
GLS2
GRIK2
GRIN1
GRIN2A
GRIN2B
GRIN2C
GUCY1A2
KCNA4
KCNJ12
KCNJ2
KDELR1
KHDRBS1
KIF1B
LIN7A
LRP2
MAPK12
NLGN1
NLGN2
NLGN3
OSBP2
PLEKHA2
PTK2B
RPS8
SCN4A
SCN5A
SEMA4C
SYNGAP1
VTN
11 interacting genes:
CASK
CD22
DLG1
DLG2
DLG3
DLG4
ERBIN
NOS1
PPP3CA
RASSF1
SRC
Entrez ID
1741
493
HPRD ID
02177
00159
Ensembl ID
ENSG00000082458
ENSG00000058668
Uniprot IDs
Q59FY1
Q92796
A0A024R968
P23634
PDB IDs
1UM7
2FE5
2I1N
1CFF
2KNE
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?