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DLG3 and PTK2B
Data Source:
HPRD
(in vitro, in vivo)
DLG3
PTK2B
Description
discs large MAGUK scaffold protein 3
protein tyrosine kinase 2 beta
Image
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Plasma Membrane
Ionotropic Glutamate Receptor Complex
Basolateral Plasma Membrane
Cell Junction
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Focal Adhesion
Cell Cortex
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Lamellipodium
Dendrite
Growth Cone
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuronal Cell Body
Dendritic Spine
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Apical Dendrite
Glutamatergic Synapse
Molecular Function
Protein Binding
Kinase Binding
Phosphatase Binding
Calmodulin-dependent Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
NMDA Glutamate Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Ubiquitin Protein Ligase Binding
3-phosphoinositide-dependent Protein Kinase Binding
Protein-containing Complex Binding
Biological Process
MAPK Cascade
Negative Regulation Of Cell Population Proliferation
Embryo Development
Negative Regulation Of Phosphatase Activity
Receptor Clustering
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Protein Tyrosine Kinase Activity
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of NMDA Receptor Activity
MAPK Cascade
Angiogenesis
Oocyte Maturation
Response To Hypoxia
Positive Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Adaptive Immune Response
Marginal Zone B Cell Differentiation
Protein Phosphorylation
Apoptotic Process
Cellular Defense Response
Response To Osmotic Stress
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Mechanical Stimulus
Response To Hormone
Response To Glucose
Response To Lithium Ion
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Muscle Cell Apoptotic Process
Regulation Of CGMP-mediated Signaling
Regulation Of Macrophage Chemotaxis
Positive Regulation Of Neuron Projection Development
Glial Cell Proliferation
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Actin Filament Polymerization
Neuron Projection Development
Regulation Of Inositol Trisphosphate Biosynthetic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Response To Immobilization Stress
Peptidyl-tyrosine Autophosphorylation
Interleukin-2-mediated Signaling Pathway
Response To Cocaine
Response To Drug
Response To Hydrogen Peroxide
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Stress Fiber Assembly
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Bone Resorption
Response To Ethanol
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Synaptic Plasticity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Calcium-mediated Signaling
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Response To CAMP
Response To Calcium Ion
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Protein-containing Complex Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Fluid Shear Stress
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Establishment Of Cell Polarity
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of B Cell Chemotaxis
Positive Regulation Of DNA Biosynthetic Process
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
Interleukin-2 signaling
Drugs
Leflunomide
Genistein
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Baricitinib
Fostamatinib
Diseases
Non-syndromic X-linked mental retardation
GWAS
Mean platelet volume (
32888494
)
Adult body size (
32376654
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
30617256
24162737
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bone mineral content (
31790847
)
Bone mineral density (
31790847
)
Crohn's disease (
26192919
)
Dental caries (
23259602
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Family history of Alzheimer's disease (
30617256
)
Inflammatory bowel disease (
26192919
)
Schizophrenia (
29483656
)
Takayasu arteritis (
25604533
30498034
)
White blood cell count (
32888494
)
Interacting Genes
48 interacting genes:
ABCA1
ADGRL1
APC
ATP2B4
CACNG2
CALM1
CNKSR2
CRIPT
DHRS11
DLG1
DLG4
DLGAP1
DLGAP2
DLGAP3
DLGAP4
EIF4H
ERBB4
EXOC4
EXOC7
GDA
GLS2
GRIK2
GRIN1
GRIN2A
GRIN2B
GRIN2C
GUCY1A2
KCNA4
KCNJ12
KCNJ2
KDELR1
KHDRBS1
KIF1B
LIN7A
LRP2
MAPK12
NLGN1
NLGN2
NLGN3
OSBP2
PLEKHA2
PTK2B
RPS8
SCN4A
SCN5A
SEMA4C
SYNGAP1
VTN
69 interacting genes:
ARHGAP21
ARHGAP5
ASAP1
ASAP2
BCAR1
CBL
CCR5
CRK
DLG3
DLG4
DLGAP3
EFS
EGFR
ERBB2
ERBB3
EWSR1
FGFR2
FGFR3
FLT1
FYN
GNA13
GRB2
GRIN2A
GSN
IL7R
ITGB2
ITGB3
JAK1
JAK2
JAK3
KCNA2
LCK
LPXN
LYN
MAP3K4
MAPT
MATK
MCAM
MYH2
NEDD9
NPHP1
PDCD6IP
PDPK1
PIK3R1
PITPNM1
PITPNM2
PITPNM3
PRKCD
PTK2
PTPN11
PTPN12
PTPN6
PXN
RASA1
RB1CC1
SH2D3C
SHC1
SKAP2
SLC2A1
SNCA
SORBS2
SRC
STAP1
STAT3
SYK
TGFB1I1
TLN1
VAV1
ZAP70
Entrez ID
1741
2185
HPRD ID
02177
03131
Ensembl ID
ENSG00000082458
ENSG00000120899
Uniprot IDs
Q59FY1
Q92796
Q14289
PDB IDs
1UM7
2FE5
2I1N
2FO6
2LK4
3CC6
3ET7
3FZO
3FZP
3FZR
3FZS
3FZT
3GM1
3GM2
3GM3
3H3C
3U3F
4EKU
4H1J
4H1M
4R32
4XEF
4XEK
4XEV
5TO8
5TOB
6LF3
Enriched GO Terms of Interacting Partners
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