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GJA5 and TMBIM6
Data Source:
BioGRID
(two hybrid)
GJA5
TMBIM6
Description
gap junction protein alpha 5
transmembrane BAX inhibitor motif containing 6
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Plasma Membrane
Gap Junction
Connexin Complex
Intercalated Disc
Cell Projection
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Membrane
Mitochondrial Membrane
Molecular Function
Gap Junction Channel Activity
Protein Binding
Gap Junction Hemi-channel Activity
Connexin Binding
Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling
Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling
Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling
Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling
Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling
Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling
Disordered Domain Specific Binding
Protein Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Endoribonuclease Inhibitor Activity
Biological Process
Angiogenesis
Negative Regulation Of Glomerular Filtration
Outflow Tract Morphogenesis
Endothelium Development
Mitral Valve Development
Pulmonary Valve Formation
Ventricular Septum Development
Atrial Septum Development
Potassium Ion Transport
Cell-cell Signaling
Cell Communication By Chemical Coupling
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Cell Communication By Chemical Coupling
Gap Junction Assembly
Negative Regulation Of Blood Pressure
Positive Regulation Of Vasoconstriction
Artery Morphogenesis
Transmembrane Transport
Regulation Of Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling
Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling
AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling
Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling
Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Regulation Of AV Node Cell Action Potential
Regulation Of Bundle Of His Cell Action Potential
Regulation Of Purkinje Myocyte Action Potential
Regulation Of Atrial Cardiac Muscle Cell Action Potential
Vasomotion
Negative Regulation Of Immunoglobulin Production
Autophagy
Negative Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Protein Binding
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of RNA Splicing
Cellular Response To Unfolded Protein
Negative Regulation Of Apoptotic Process
Negative Regulation Of Endoribonuclease Activity
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Response To L-glutamate
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Gap junction assembly
Drugs
Diseases
Atrial fibrillation
GWAS
Atrial fibrillation (
30061737
29892015
)
Cognitive performance (
20125193
)
Methotrexate-induced interstitial lung disease in rheumatoid arthritis (
28500057
)
PR interval (
32439900
)
General cognitive ability (
29844566
)
Interacting Genes
34 interacting genes:
AAR2
ABHD16A
BLCAP
C4orf3
EMP3
FCER1G
GJA1
GJB2
IGFBP5
LEPROT
LEPROTL1
LHFPL2
MARK1
MFSD5
MS4A13
NIPAL3
NKG7
PGAP2
PRAF2
PRKACA
RIMS3
RPRM
SLC13A4
SLC30A2
SLC35F1
SLC41A1
SLC41A2
SLC66A1
TMBIM6
TMEM107
TREX1
UBQLN4
VRK2
YIPF6
68 interacting genes:
ADIPOR2
ATP13A1
BCL2
BCL2L1
CD300LG
CD79A
CD99L2
CDC7
CERS2
CLDN22
COBLL1
CREB3L1
EBP
ENPP4
ERP29
ESAM
FAM209A
FERD3L
FGFBP2
FXYD3
GJA5
GJA8
GJB4
GLP1R
GPHB5
GPR151
GPR42
GPX8
GYPA
GZMK
HERPUD2
HJV
HTR2C
IER3
JSRP1
KCNA10
KCNC1
LIME1
LRRC59
MANBAL
MFSD14B
MMGT1
MS4A3
ODF4
OPRM1
PI16
PIANP
PVR
REEP2
RHBDL2
RNF185
SCN3B
SIT1
SLAMF6
SLC12A7
SLC41A3
SLC7A1
SOAT2
STEAP1B
SYT9
TEX29
TMEM31
TMUB1
TMX2
TNFRSF17
TREML1
UGT2B11
VTI1A
Entrez ID
2702
7009
HPRD ID
08699
02851
Ensembl ID
ENSG00000265107
ENSG00000139644
Uniprot IDs
P36382
X5D2H9
A0A024R0Z5
P55061
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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