TMBIM6 and CERS2

Data Source:
BioGRID (two hybrid)

		TMBIM6	CERS2
Description		transmembrane BAX inhibitor motif containing 6	ceramide synthase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Mitochondrial Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Negative Regulation Of Apoptotic Process Negative Regulation Of Endoribonuclease Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		68 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MFSD14B MMGT1 MS4A3 ODF4 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 RNF185 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	12 interacting genes: ASGR1 ASGR2 ATP6V0C DRD2 HSP90AA1 IER3IP1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 YIF1A
Entrez ID		7009	29956
HPRD ID		02851	06080
Ensembl ID		ENSG00000139644	ENSG00000143418
Uniprot IDs		A0A024R0Z5 P55061	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?
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