TMBIM6 and ESAM

Data Source:
BioGRID (two hybrid)

		TMBIM6	ESAM
Description		transmembrane BAX inhibitor motif containing 6	endothelial cell adhesion molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Mitochondrial Membrane	Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Protein Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Negative Regulation Of Apoptotic Process Negative Regulation Of Endoribonuclease Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Actin Filament Polymerization Cellular Protein Localization Maintenance Of Blood-brain Barrier Leukocyte Migration Bicellular Tight Junction Assembly Cell-cell Adhesion Regulation Of Actin Cytoskeleton Reorganization
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Schizophrenia ( 25056061 29483656)
Interacting Genes		68 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MFSD14B MMGT1 MS4A3 ODF4 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 RNF185 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	3 interacting genes: C3orf52 MTDH TMBIM6
Entrez ID		7009	90952
HPRD ID		02851	13280
Ensembl ID		ENSG00000139644	ENSG00000149564
Uniprot IDs		A0A024R0Z5 P55061	Q96AP7
PDB IDs
Enriched GO Terms of Interacting Partners?
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