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GJA5 and GJB2
Data Source:
BioGRID
(two hybrid)
GJA5
GJB2
Description
gap junction protein alpha 5
gap junction protein beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Plasma Membrane
Gap Junction
Connexin Complex
Intercalated Disc
Cell Projection
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Gap Junction
Connexin Complex
Lateral Plasma Membrane
Cell Body
Perinuclear Region Of Cytoplasm
Astrocyte Projection
Molecular Function
Gap Junction Channel Activity
Protein Binding
Gap Junction Hemi-channel Activity
Connexin Binding
Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling
Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling
Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling
Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling
Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling
Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling
Disordered Domain Specific Binding
Gap Junction Channel Activity
Calcium Ion Binding
Protein Binding
Identical Protein Binding
Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
Biological Process
Angiogenesis
Negative Regulation Of Glomerular Filtration
Outflow Tract Morphogenesis
Endothelium Development
Mitral Valve Development
Pulmonary Valve Formation
Ventricular Septum Development
Atrial Septum Development
Potassium Ion Transport
Cell-cell Signaling
Cell Communication By Chemical Coupling
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Cell Communication By Chemical Coupling
Gap Junction Assembly
Negative Regulation Of Blood Pressure
Positive Regulation Of Vasoconstriction
Artery Morphogenesis
Transmembrane Transport
Regulation Of Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling
Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling
AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling
Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling
Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Regulation Of AV Node Cell Action Potential
Regulation Of Bundle Of His Cell Action Potential
Regulation Of Purkinje Myocyte Action Potential
Regulation Of Atrial Cardiac Muscle Cell Action Potential
Vasomotion
Response To Ischemia
Cell-cell Signaling
Aging
Sensory Perception Of Sound
Cell Communication By Electrical Coupling
Gap Junction Assembly
Response To Estradiol
Response To Lipopolysaccharide
Response To Retinoic Acid
Response To Progesterone
Cellular Response To Oxidative Stress
Response To Human Chorionic Gonadotropin
Response To Antibiotic
Decidualization
Inner Ear Development
Transmembrane Transport
Cellular Response To Glucagon Stimulus
Cellular Response To Dexamethasone Stimulus
Epididymis Development
Gap Junction-mediated Intercellular Transport
Pathways
Gap junction assembly
Oligomerization of connexins into connexons
Transport of connexins along the secretory pathway
Gap junction assembly
Transport of connexons to the plasma membrane
Drugs
Diseases
Atrial fibrillation
Keratitis-ichthyosis-deafness syndrome
Palmoplantar keratoderma with deafness
Deafness, autosomal dominant
Deafness, autosomal recessive
Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS
Atrial fibrillation (
30061737
29892015
)
Cognitive performance (
20125193
)
Methotrexate-induced interstitial lung disease in rheumatoid arthritis (
28500057
)
PR interval (
32439900
)
Facial emotion recognition (happy faces) (
28608620
)
Interacting Genes
34 interacting genes:
AAR2
ABHD16A
BLCAP
C4orf3
EMP3
FCER1G
GJA1
GJB2
IGFBP5
LEPROT
LEPROTL1
LHFPL2
MARK1
MFSD5
MS4A13
NIPAL3
NKG7
PGAP2
PRAF2
PRKACA
RIMS3
RPRM
SLC13A4
SLC30A2
SLC35F1
SLC41A1
SLC41A2
SLC66A1
TMBIM6
TMEM107
TREX1
UBQLN4
VRK2
YIPF6
43 interacting genes:
AMIGO1
APLNR
AQP6
ARL13B
CAV1
CD14
CNST
CREB3
EBP
ERGIC3
FAM209A
FFAR2
GJA5
GJA8
GJB1
GJB6
GPR152
GPR42
HSD17B13
KCNK5
KLRC1
LHFPL5
LMNA
LRRC4C
MFSD6
MS4A6E
PEX12
PLEKHB2
SAR1A
SHISAL1
SLC18A1
SLC30A2
SSMEM1
TBXA2R
TEX29
TIMMDC1
TLCD4
TM2D2
TMEM106A
TMEM237
TMEM31
TMX2
TRHR
Entrez ID
2702
2706
HPRD ID
08699
00413
Ensembl ID
ENSG00000265107
ENSG00000165474
Uniprot IDs
P36382
X5D2H9
H9U1J4
P29033
PDB IDs
1XIR
2ZW3
3IZ1
3IZ2
5ER7
5ERA
5KJ3
5KJG
6UVR
6UVS
6UVT
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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