MAGI3 and PLXNB3

Data Source:
HPRD (two hybrid)

		MAGI3	PLXNB3
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	plexin B3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways			Other semaphorin interactions
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2	8 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		260425	5365
HPRD ID		11290	02198
Ensembl ID		ENSG00000081026	ENSG00000198753
Uniprot IDs		Q5TCQ9	A8K920 Q9ULL4
PDB IDs		3SOE
Enriched GO Terms of Interacting Partners?
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