MAGI3 and VANGL2

Data Source:
HPRD (in vitro, in vivo)

		MAGI3	VANGL2
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	VANGL planar cell polarity protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction	Plasma Membrane Cell-cell Junction Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process	Establishment Of Planar Polarity Neural Tube Closure Heart Looping Cell Migration Involved In Kidney Development Apical Protein Localization Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-motile Cilium Assembly
Pathways			PCP/CE pathway Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Left-handedness ( 32989287) Multiple sclerosis ( 31604244 24076602) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)
Interacting Genes		16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2	5 interacting genes: AP1M1 ARFRP1 DVL1 MAGI3 SQSTM1
Entrez ID		260425	57216
HPRD ID		11290	02758
Ensembl ID		ENSG00000081026	ENSG00000162738
Uniprot IDs		Q5TCQ9	A8K4L6 Q9ULK5
PDB IDs		3SOE
Enriched GO Terms of Interacting Partners?
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