MAGI3 and PTPRB

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MAGI3	PTPRB
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	protein tyrosine phosphatase receptor type B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction	Plasma Membrane Integral Component Of Plasma Membrane Specific Granule Membrane Receptor Complex Tertiary Granule Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Cadherin Binding
	Biological Process	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Neutrophil Degranulation Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways			Neutrophil degranulation
Drugs			{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (4-ETHYLPHENYL)SULFAMIC ACID Razuprotafib
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2	11 interacting genes: CDH5 CNTN1 CNTNAP1 EGFR F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		260425	5787
HPRD ID		11290	01474
Ensembl ID		ENSG00000081026	ENSG00000127329
Uniprot IDs		Q5TCQ9	F8VU56 P23467 Q68D73 Q86VA4
PDB IDs		3SOE	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X
Enriched GO Terms of Interacting Partners?
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