MAPK8IP2 and MAPK8

Data Source:
HPRD (in vivo, in vitro)

		MAPK8IP2	MAPK8
Description		mitogen-activated protein kinase 8 interacting protein 2	mitogen-activated protein kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Axon Synapse Basal Dendrite
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein-containing Complex Binding	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding
	Biological Process	Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Signaling Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway	Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Histone Deacetylation Positive Regulation Of Cyclase Activity Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Cytokine Stimulus Positive Regulation Of Deacetylase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of DNA Replication Origin Binding
Pathways			Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation DSCAM interactions JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping
Drugs			Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
Diseases
GWAS		Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Blood protein levels in cardiovascular risk ( 28369058) Daytime sleep phenotypes ( 27126917) Refractive error ( 32231278)
Interacting Genes		85 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	137 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SERPINB4 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605
Entrez ID		23542	5599
HPRD ID		09674	03100
Ensembl ID		ENSG00000008735	ENSG00000107643
Uniprot IDs		Q13387	A1L4K2 P45983
PDB IDs			1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E
Enriched GO Terms of Interacting Partners?
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