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MAPK8 and TP73
Data Source:
HPRD
(in vivo, in vitro)
MAPK8
TP73
Description
mitogen-activated protein kinase 8
tumor protein p73
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Axon
Synapse
Basal Dendrite
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Metal Ion Binding
MDM2/MDM4 Family Protein Binding
Biological Process
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Positive Regulation Of Cyclase Activity
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Rhythmic Process
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Cytokine Stimulus
Positive Regulation Of Deacetylase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of DNA Replication Origin Binding
Activation Of MAPK Activity
Kidney Development
Mismatch Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Organonitrogen Compound
Regulation Of Gene Expression
Viral Process
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hepatocellular carcinoma
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Refractive error (
32231278
)
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Interacting Genes
137 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
63 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
SUMO1
TP53
TP63
TRIM28
UBE2D3
UBE2I
WT1
WWOX
XPO1
YAP1
Entrez ID
5599
7161
HPRD ID
03100
03587
Ensembl ID
ENSG00000107643
ENSG00000078900
Uniprot IDs
A1L4K2
P45983
A0A0C4DFW9
A1PQX5
O15350
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
Enriched GO Terms of Interacting Partners
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