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MAPK8IP2 and RBX1
Data Source:
BioGRID
(two hybrid)
MAPK8IP2
RBX1
Description
mitogen-activated protein kinase 8 interacting protein 2
ring-box 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Postsynaptic Density
Protein-containing Complex
Neuronal Cell Body
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Molecular Function
Amyloid-beta Binding
MAP-kinase Scaffold Activity
Structural Molecule Activity
Protein Binding
Kinesin Binding
Protein Kinase Binding
Protein-containing Complex Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Biological Process
Behavioral Fear Response
Signal Complex Assembly
JNK Cascade
Mating Behavior
Regulation Of Signaling Receptor Activity
Positive Regulation Of Stress-activated MAPK Cascade
Social Behavior
Regulation Of JNK Cascade
Nonassociative Learning
Dendrite Morphogenesis
Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Regulation Of NMDA Receptor Activity
Regulation Of AMPA Receptor Activity
Negative Regulation Of Apoptotic Signaling Pathway
MAPK Cascade
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
Protein Phosphopantetheinylation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleotide-excision Repair, DNA Incision
DNA Damage Response, Detection Of DNA Damage
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Protein K48-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Gut microbiota relative abundance (Prevotella) (
33208821
)
Hip circumference (
28552196
)
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Interacting Genes
85 interacting genes:
ADRB2
AFG3L2
ANAPC10
APP
ASRGL1
BBS10
C1QTNF3
C22orf39
C8orf33
CFL1
CHN1
CRMP1
CRP
CTNNBL1
DUSP16
DUSP18
EGFR
ERBB2
ERG28
EZH2
FGF12
FGF13
FSCN1
GALNT3
GBP2
HLA-C
HOXC8
IGIP
ING4
ITSN1
KIFC2
KLC1
LEFTY2
LRP1
LRP2
LRP8
LSM8
MAGED4B
MAP2K3
MAP2K7
MAP3K10
MAP3K11
MAP3K12
MAPK10
MAPK8
MAPK8IP1
MAPK8IP3
MAPK9
MASP1
MNDA
MRE11
MSRB3
NDUFS6
NUMB
PLXNA3
POLR1H
PRSS23
RAI1
RBM4
RBX1
RPS6KB2
RYBP
SCLT1
SH2D1B
SLC39A13
SLPI
SMARCB1
SMS
SPINK2
SPSB3
SRP19
SYNE2
TARBP2
TIAM1
TMEM128
TP53BP2
UNC119
USP46
VCP
VPS33B
VRK2
YY1AP1
ZNF593
ZNF670
ZNF784
65 interacting genes:
APP
ARIH1
CAND1
CAND2
CCND1
CDC34
CDKN1B
COPS4
COPS6
CRBN
CSNK1E
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
DCAF1
DTL
ERBIN
ERCC8
FBH1
FBXW8
FRZB
GHR
GLMN
GPS1
HAX1
KCTD17
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
OS9
PBX4
PML
PRAME
RHOBTB3
RNF126
RPS6KB1
SERTAD1
SKP1
SMAD3
TAB1
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VRK2
Entrez ID
23542
9978
HPRD ID
09674
06794
Ensembl ID
ENSG00000008735
ENSG00000100387
Uniprot IDs
Q13387
P62877
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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