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MAPK8 and MBP
Data Source:
BioGRID
(enzymatic study)
MAPK8
MBP
Description
mitogen-activated protein kinase 8
myelin basic protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Axon
Synapse
Basal Dendrite
Nucleus
Plasma Membrane
Cell Surface
Protein-containing Complex
Internode Region Of Axon
Neuronal Cell Body
Myelin Sheath
Compact Myelin
Synapse
Cell Periphery
Molecular Function
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Protease Binding
Protein Binding
Calmodulin Binding
Structural Constituent Of Myelin Sheath
Biological Process
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Positive Regulation Of Cyclase Activity
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Rhythmic Process
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Cytokine Stimulus
Positive Regulation Of Deacetylase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of DNA Replication Origin Binding
MAPK Cascade
Immune Response
Chemical Synaptic Transmission
Central Nervous System Development
Sensory Perception Of Sound
Axon Ensheathment
Response To Toxic Substance
Substantia Nigra Development
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Maintenance Of Blood-brain Barrier
Myelination
Membrane Organization
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Refractive error (
32231278
)
Age-related macular degeneration (geographic atrophy) (
22705344
)
Blood osmolality (transformed sodium) (
28360221
)
Depression in smokers (
30219690
)
Erythrocyte cadmium concentration in never smokers (
27005419
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Verbal declarative memory (
25648963
)
Interacting Genes
137 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
81 interacting genes:
ABL1
ADRB2
APTX
ATN1
ATXN1
AURKA
BMP2K
CCR1
CDK1
CDK12
CDK5
CDK7
CDK8
CDK9
CLK1
CTDSP1
CTDSPL
DYRK1B
HIPK2
HLA-DRA
IKBKE
ILK
IRAK1
IRAK4
LIMK1
LIMK2
LRRK2
MAG
MAP2K1
MAP3K1
MAP3K3
MAP3K5
MAPK1
MAPK11
MAPK12
MAPK13
MAPK14
MAPK15
MAPK3
MAPK8
MAPKAPK5
MELK
MICU2
MKNK1
MMP7
NEK9
PAK1
PDGFRL
PKN1
PLEKHF2
PLP1
PPP2R5C
PRKACA
PRKCA
PRKCB
PRKCD
PRKCI
PRKCZ
PRKDC
PRMT1
PRMT5
PTAFR
PTPRA
RAF1
RAN
RPS6KA5
RTN4
SQSTM1
SRPK1
STK16
STK26
STK3
STK39
STK4
TBK1
TLK1
TLK2
TRAF6
TRPM7
TSSK6
ULK1
Entrez ID
5599
4155
HPRD ID
03100
01158
Ensembl ID
ENSG00000107643
ENSG00000197971
Uniprot IDs
A1L4K2
P45983
A0A024R384
P02686
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
1BX2
1FV1
1HQR
1K2D
1QCL
1YMM
1ZGL
Enriched GO Terms of Interacting Partners
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