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MAPK8 and DUSP4
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
HPRD
(in vivo)
MAPK8
DUSP4
Description
mitogen-activated protein kinase 8
dual specificity phosphatase 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Axon
Synapse
Basal Dendrite
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/threonine Phosphatase Activity
Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Mitogen-activated Protein Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
MAP Kinase Serine/threonine Phosphatase Activity
Biological Process
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Positive Regulation Of Cyclase Activity
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Rhythmic Process
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Cytokine Stimulus
Positive Regulation Of Deacetylase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of DNA Replication Origin Binding
Inactivation Of MAPK Activity
Endoderm Formation
Protein Dephosphorylation
Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Peptidyl-threonine Dephosphorylation
Negative Regulation Of ERK1 And ERK2 Cascade
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Refractive error (
32231278
)
Gestational age at birth (maternal effect) (
28598419
)
Postoperative complication after cardiac surgery (
30678657
)
Response to statin therapy (
20339536
)
Spontaneous preterm birth (maternal effect) (
28598419
)
Interacting Genes
137 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
19 interacting genes:
APP
CRMP1
GORASP2
GRIN1
GRIN2D
LYSMD1
LYSMD2
LZTS2
MAPK1
MAPK14
MAPK3
MAPK8
MAPK9
NOXA1
PLEKHF2
TEPSIN
TRAF1
ZNF426
ZNF655
Entrez ID
5599
1846
HPRD ID
03100
04123
Ensembl ID
ENSG00000107643
ENSG00000120875
Uniprot IDs
A1L4K2
P45983
Q13115
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
3EZZ
Enriched GO Terms of Interacting Partners
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