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MAPK8 and GSTP1
Data Source:
HPRD
(in vivo, in vitro)
MAPK8
GSTP1
Description
mitogen-activated protein kinase 8
glutathione S-transferase pi 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Axon
Synapse
Basal Dendrite
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Vesicle
Secretory Granule Lumen
Extracellular Exosome
TRAF2-GSTP1 Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Glutathione Transferase Activity
Glutathione Peroxidase Activity
Fatty Acid Binding
Protein Binding
Drug Binding
JUN Kinase Binding
Kinase Regulator Activity
S-nitrosoglutathione Binding
Dinitrosyl-iron Complex Binding
Glutathione Binding
Nitric Oxide Binding
Biological Process
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Positive Regulation Of Cyclase Activity
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Rhythmic Process
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Cytokine Stimulus
Positive Regulation Of Deacetylase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of DNA Replication Origin Binding
Response To Reactive Oxygen Species
Negative Regulation Of Acute Inflammatory Response
Negative Regulation Of Protein Kinase Activity
Prostaglandin Metabolic Process
Glutathione Metabolic Process
Xenobiotic Metabolic Process
Central Nervous System Development
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Oligodendrocyte Development
Animal Organ Regeneration
Response To Estradiol
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Superoxide Anion Generation
Response To L-ascorbic Acid
Cellular Response To Oxidative Stress
Common Myeloid Progenitor Cell Proliferation
Nitric Oxide Storage
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Negative Regulation Of JUN Kinase Activity
Linoleic Acid Metabolic Process
Response To Ethanol
Negative Regulation Of Fibroblast Proliferation
Hepoxilin Biosynthetic Process
Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Lipopolysaccharide
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Cell-matrix Adhesion
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Negative Regulation Of Smooth Muscle Cell Chemotaxis
Cellular Oxidant Detoxification
Glutathione Derivative Biosynthetic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
DSCAM interactions
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Glutathione
Troglitazone
Clozapine
Etacrynic acid
Clomipramine
(9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
S-Hydroxycysteine
Cibacron Blue
Glutathione sulfonic acid
Glutathione disulfide
Deoxycholic acid
S-(4-nitrobenzyl)glutathione
2-(N-morpholino)ethanesulfonic acid
S-Hexylglutathione
Carbocisteine
Canfosfamide
Ezatiostat
Exisulind
S-NONYL-CYSTEINE
S-(4-BROMOBENZYL)CYSTEINE
Curcumin
Dinitrochlorobenzene
Hypericin
Curcumin sulfate
Diseases
Prostate cancer
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Refractive error (
32231278
)
Blood protein levels (
29875488
)
Refractive error (
32231278
)
Interacting Genes
137 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
35 interacting genes:
ADAMTSL4
APPBP2
CARD10
CYSRT1
FANCC
FHL5
HOXA1
KRT31
KRT33B
KRT34
KRT83
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-9
KRTAP3-1
KRTAP3-3
KRTAP6-2
LRP2BP
MAPK8
MLH1
MTUS2
NBPF19
NOTCH2NLA
PNO1
PRDX6
PTN
SCAF1
SH3GLB1
SUMO4
TGM1
TGM2
TRAF2
ZNF655
Entrez ID
5599
2950
HPRD ID
03100
00614
Ensembl ID
ENSG00000107643
ENSG00000084207
Uniprot IDs
A1L4K2
P45983
P09211
V9HWE9
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
10GS
11GS
12GS
13GS
14GS
16GS
17GS
18GS
19GS
1AQV
1AQW
1AQX
1EOG
1EOH
1GSS
1KBN
1LBK
1MD3
1MD4
1PGT
1PX6
1PX7
1ZGN
20GS
22GS
2A2R
2A2S
2GSS
2J9H
2PGT
3CSH
3CSI
3CSJ
3DD3
3DGQ
3GSS
3GUS
3HJM
3HJO
3HKR
3IE3
3KM6
3KMN
3KMO
3N9J
3PGT
4GSS
4PGT
5DAK
5DAL
5DCG
5DDL
5DJL
5DJM
5GSS
5J41
5JCW
5L6X
5X79
6AP9
6GSS
6Y1E
7GSS
8GSS
9GSS
Enriched GO Terms of Interacting Partners
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