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TNS2 and TSC1
Data Source:
BioGRID
(two hybrid)
TNS2
TSC1
Description
tensin 2
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Molecular Function
Protein Tyrosine Phosphatase Activity
Protein Binding
Kinase Binding
Identical Protein Binding
Metal Ion Binding
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Biological Process
Kidney Development
Negative Regulation Of Cell Population Proliferation
Response To Muscle Activity
Cellular Homeostasis
Collagen Metabolic Process
Multicellular Organism Growth
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Negative Regulation Of Insulin Receptor Signaling Pathway
Multicellular Organismal Homeostasis
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
150 interacting genes:
ADCK5
AMMECR1
AP1S2
AQP1
ARID5A
ASB3
AXL
BAHD1
BLZF1
BRCA1
C11orf87
C1orf94
CATSPER1
CCDC33
CNNM3
COX6B2
CPSF7
CRX
CSNK1E
CTSZ
DCAF11
DCAF8
DDIT4L
DLC1
DOK3
DZIP1
DZIP3
EGFR
ENKD1
EPB41L4A
EPDR1
EPS8L2
ERBB2
ERBB3
ERBB4
FABP7
FAM114A1
FAM228A
FASLG
FGF21
FGFR1
FOXO1
GATA1
GBA3
GFI1B
HOXA1
HOXB9
HOXC8
HUWE1
ID2
IHO1
INO80B
ITGB3
ITGB5
ITGB7
KCTD9
KIF1A
KIT
KPRP
KRT76
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP12-3
KRTAP13-1
KRTAP13-2
KRTAP23-1
KRTAP3-1
KRTAP4-4
KRTAP6-3
LASP1
LPXN
LUZP4
MET
MGAT5B
MPEG1
MT2A
MTDH
MYBPHL
MYH7B
MYPOP
NBPF19
NMU
NOTCH2NLA
NT5C
NUBP2
OBSL1
OTX1
PATZ1
PER1
PHF1
PIN1
PKP1
PLB1
PLK3
PLSCR3
POLR1H
POLR3F
PRR22
RAMAC
RBAK
RBPMS
REEP6
REL
RFT1
RNF6
SDCCAG8
SERTAD2
SH2B3
SHFL
SOCS7
SORBS3
SPATA12
SPRY2
SPRY4
SUSD2
SUV39H1
TBC1D16
TCP10L
TEKT3
TEKT5
TENT5A
TENT5B
TFAP2D
TLE5
TM4SF19
TRIM8
TSC1
TWSG1
USP54
WAC
WDFY3
ZCCHC14
ZIM2
ZNF134
ZNF205
ZNF250
ZNF417
ZNF497
ZNF575
ZNF586
ZNF587
ZNF648
ZNF655
ZNF688
ZNF837
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
Entrez ID
23371
7248
HPRD ID
16256
05594
Ensembl ID
ENSG00000111077
ENSG00000165699
Uniprot IDs
A0A024RB48
Q63HR2
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
2DKQ
2KNO
2L6K
2LOZ
3HQC
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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