TSC1 and SUOX

Data Source:
BioGRID (two hybrid)

		TSC1	SUOX
Description		TSC complex subunit 1	sulfite oxidase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex	Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding	Protein Binding Sulfite Oxidase Activity Heme Binding Molybdenum Ion Binding Molybdopterin Cofactor Binding
	Biological Process	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death	Sulfur Compound Metabolic Process Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs	Sulfide oxidation to sulfate
Drugs			{[2-Amino-4-oxo-6,7-di(sulfanyl-ÎºS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)sulfanylmolybdenum
Diseases		Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Migraine without aura ( 23793025) Psoriasis ( 19169254)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 32296059 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 31527586) Intelligence (MTAG) ( 29326435) Medication use (glucocorticoids) ( 31015401) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 22885925) Refractive error ( 32231278) Type 1 diabetes ( 18198356 31152121) Vitiligo ( 22951725)
Interacting Genes		99 interacting genes: AKT1 APPL2 AQP1 ARAF ARID5A ATXN1 AURKA BAG3 BECN1 C1orf94 CCDC120 CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CHCHD2 CSTF2 DMRT3 DOK5 ENKD1 EZR FAM110A FAM222B FGFR4 FOXH1 FRS3 GLIS2 GPANK1 HOXC8 HR HSH2D IGFN1 IKBKB KAT2A KDM1A LATS2 LENG1 LMO2 MAP2K5 MAPK14 MSN MYC MYLIP MYOZ3 NEFL NF2 PATL1 PATZ1 PITX1 PLK1 PLK2 POGZ POU6F2 PPP1R18 PPP1R32 PRMT6 RASSF1 RBPMS RDX RHEB RIN1 RIN3 SAMD11 SAMD7 SH2D2A SHC3 SMG9 SOX4 SPAG8 SUOX TBC1D7 TBX6 TCF7L2 TFAP2D TLE5 TNS2 TSC2 TSGA10IP TSHZ3 VENTX VEZF1 VGLL3 VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF587 ZNF765	77 interacting genes: ACOT11 BAG4 C1D C5orf51 CAMK2A CCDC103 CDCA4 CEP76 COA7 COPS8 CRX CTAG1A CTAG1B CYB5R2 DMAP1 DUSP21 EIF3F ERICH4 EYA2 FAM217B FMNL2 FMR1 FNDC3B GOLGA6L9 HADHB HMG20A INCA1 ING5 ISCA2 ITGB3BP KIAA0753 KRT26 KRT27 KRT34 KRT40 LMO4 MAGEA11 MAGEB10 MBD3L1 MDFI MED28 MEIS3 MORN3 MYL7 MYO1B NUP62 PEX19 PIH1D2 POMC PRRX1 PTTG2 REL RELA RHOH RINT1 RPLP1 RSKR RUSC1 SERTAD3 SGTA SH3BP5L SNF8 SOHLH1 SPC24 STAT5B STH SYNGAP1 TEX12 TRIB3 TSC1 UBQLN2 UBR2 VBP1 VPS28 ZNF143 ZNF576 ZXDC
Entrez ID		7248	6821
HPRD ID		05594	06055
Ensembl ID		ENSG00000165699	ENSG00000139531
Uniprot IDs		A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2	A0A024RB79 P51687
PDB IDs		4Z6Y 5EJC	1MJ4
Enriched GO Terms of Interacting Partners?
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