TNS2 and DCAF8

Data Source:
BioGRID (two hybrid)

		TNS2	DCAF8
Description		tensin 2	DDB1 and CUL4 associated factor 8
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal Homeostasis	Protein Ubiquitination Post-translational Protein Modification
Pathways			Neddylation
Drugs
Diseases
GWAS			Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837	12 interacting genes: DDB1 GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBPMS SUV39H1 THAP1 TNS2 TRIM54
Entrez ID		23371	50717
HPRD ID		16256	18300
Ensembl ID		ENSG00000111077	ENSG00000132716
Uniprot IDs		A0A024RB48 Q63HR2	B7Z8C9 Q5TAQ9
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC	3I8E
Enriched GO Terms of Interacting Partners?
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