TNS2 and ZNF648

Data Source:
BioGRID (two hybrid)

		TNS2	ZNF648
Description		tensin 2	zinc finger protein 648
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Nucleus
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Kidney Development Negative Regulation Of Cell Population Proliferation Response To Muscle Activity Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Multicellular Organismal Homeostasis	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cardiovascular heart disease in diabetics ( 23982368) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Morning person ( 30696823) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		150 interacting genes: ADCK5 AMMECR1 AP1S2 AQP1 ARID5A ASB3 AXL BAHD1 BLZF1 BRCA1 C11orf87 C1orf94 CATSPER1 CCDC33 CNNM3 COX6B2 CPSF7 CRX CSNK1E CTSZ DCAF11 DCAF8 DDIT4L DLC1 DOK3 DZIP1 DZIP3 EGFR ENKD1 EPB41L4A EPDR1 EPS8L2 ERBB2 ERBB3 ERBB4 FABP7 FAM114A1 FAM228A FASLG FGF21 FGFR1 FOXO1 GATA1 GBA3 GFI1B HOXA1 HOXB9 HOXC8 HUWE1 ID2 IHO1 INO80B ITGB3 ITGB5 ITGB7 KCTD9 KIF1A KIT KPRP KRT76 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP23-1 KRTAP3-1 KRTAP4-4 KRTAP6-3 LASP1 LPXN LUZP4 MET MGAT5B MPEG1 MT2A MTDH MYBPHL MYH7B MYPOP NBPF19 NMU NOTCH2NLA NT5C NUBP2 OBSL1 OTX1 PATZ1 PER1 PHF1 PIN1 PKP1 PLB1 PLK3 PLSCR3 POLR1H POLR3F PRR22 RAMAC RBAK RBPMS REEP6 REL RFT1 RNF6 SDCCAG8 SERTAD2 SH2B3 SHFL SOCS7 SORBS3 SPATA12 SPRY2 SPRY4 SUSD2 SUV39H1 TBC1D16 TCP10L TEKT3 TEKT5 TENT5A TENT5B TFAP2D TLE5 TM4SF19 TRIM8 TSC1 TWSG1 USP54 WAC WDFY3 ZCCHC14 ZIM2 ZNF134 ZNF205 ZNF250 ZNF417 ZNF497 ZNF575 ZNF586 ZNF587 ZNF648 ZNF655 ZNF688 ZNF837	61 interacting genes: AXIN2 BEGAIN BICD2 CALCOCO2 CARD14 CCDC120 CCDC136 CCDC57 CDR2L CEP70 CYSRT1 DVL3 EVI5L FSD2 GOLGA2 GOLGA6L9 HAP1 HOOK2 HSF2BP KANK2 KRTAP1-1 KRTAP10-8 KRTAP12-3 LDOC1 LZTS2 MCC MDFI MEOX2 MID2 MTUS2 NBPF19 NOTCH2NLA NUDT22 OSBPL3 PLEKHG4 RBAK RINT1 RUBCN SSX2IP SYNE4 TEX19 TNS2 TRAF1 TRAF2 TRIM41 ZBTB8A ZCCHC13 ZNF250 ZNF260 ZNF275 ZNF317 ZNF343 ZNF438 ZNF552 ZNF620 ZNF655 ZNF71 ZNF768 ZNF792 ZNF837 ZRANB1
Entrez ID		23371	127665
HPRD ID		16256	18361
Ensembl ID		ENSG00000111077	ENSG00000179930
Uniprot IDs		A0A024RB48 Q63HR2	Q5T619
PDB IDs		2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?
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