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TSC1 and ZNF417
Data Source:
BioGRID
(two hybrid)
TSC1
ZNF417
Description
TSC complex subunit 1
zinc finger protein 417
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Nucleus
Molecular Function
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Biological Process
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Regulation Of Transcription By RNA Polymerase II
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Generic Transcription Pathway
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Depression in smokers (
30219690
)
Interacting Genes
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
169 interacting genes:
ADAMTSL4
AXIN2
BEGAIN
BEND5
BEX3
BHLHB9
BICD2
C4orf17
CARD9
CBY2
CCDC125
CCDC136
CCDC57
CCDC85B
CCNDBP1
CDR2
CDR2L
CEP44
CEP70
CEP72
CEP85L
CHRDL2
COG6
CSRNP1
CYSRT1
DEF8
DVL3
EFS
EZHIP
FAM221A
FHL2
FHL3
FHL5
FRS3
FSD2
FXR1
GOLGA2
GOLGA6L9
HMBOX1
HOMEZ
HOOK2
HOXA1
HSF2BP
IGFBP6
IHO1
IKZF1
INKA1
JADE2
JRK
KAT5
KATNBL1
KCTD7
KIF9
KIFC3
KLC3
KRT15
KRT31
KRT35
KRT38
KRT39
KRT40
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-9
KXD1
LHX3
LIMS1
LMO1
LURAP1
LZTS1
LZTS2
MAGEA8
MAST2
MCC
MCCD1
MDFI
MEIS3
MEOX2
MID2
MIIP
MRFAP1L1
MTUS2
MYF5
MYLIP
NAB2
NBPF19
NDEL1
NDUFB7
NINL
NKAPL
NKX3-1
NOTCH2NLA
OIP5
PHC2
PICK1
PIH1D2
PLSCR1
PNMA2
PRICKLE4
PRPF31
RCN3
REL
RHOQ
RNF187
RORB
RPGRIP1
RUNDC3A
SH2B2
SMARCD1
SMYD5
SPRED1
SPRED2
SPRY1
SPRY2
SSX2IP
STX11
SUV39H1
TADA2A
TCF4
TEKT4
TFIP11
TLE5
TMCC2
TNS2
TRAF1
TRAF2
TRIB3
TRIM23
TRIM27
TRIM36
TRIM37
TRIM41
TRIM54
TSC1
TSGA10
TXNDC11
U2AF1
U2AF1L5
USHBP1
VPS16
VPS52
VWC2
ZBTB1
ZBTB10
ZBTB43
ZBTB8A
ZBTB9
ZNF165
ZNF19
ZNF20
ZNF547
ZNF572
ZNF587
ZNF69
ZNF71
ZNF768
ZNF774
ZNF837
ZNF85
ZRANB1
Entrez ID
7248
147687
HPRD ID
05594
18341
Ensembl ID
ENSG00000165699
ENSG00000173480
Uniprot IDs
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
M0R230
Q8TAU3
PDB IDs
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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