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TSC1 and SHC3
Data Source:
BioGRID
(two hybrid)
TSC1
SHC3
Description
TSC complex subunit 1
SHC adaptor protein 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Cellular_component
Cytosol
Plasma Membrane
Molecular Function
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Phosphotyrosine Residue Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Biological Process
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Axon Guidance
Central Nervous System Development
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Signalling to RAS
Signalling to RAS
RAF/MAP kinase cascade
RET signaling
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Logical memory (delayed recall) in Alzheimer's disease dementia (
29274321
)
Pelvic organ prolapse (moderate/severe) (
26545240
)
Response to statins (LDL cholesterol change) (
22331829
)
Superior parietal cortex volume (
31530798
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
58 interacting genes:
ALK
ANKRD10
APP
AR
ARHGAP32
ASPG
AXL
BMF
CCNC
CDCA4
CEACAM6
COPS6
CT55
DOK3
EGFR
ERBB2
ERBB3
ERBB4
FLT4
FTO
GAB1
GOLGA2
GOLGA6L9
GRB2
KIT
KRT31
KRT33B
KRT34
KRT35
KRT39
KRT40
KRT86
MET
NTRK1
NTRK2
PMF1
PNMA1
PPP1R16B
PRKAR1B
PSMD8
REL
RET
SH3GL3
SMYD3
STX11
TRAF1
TRAF2
TRIM35
TRIM54
TSC1
UBAP2
USHBP1
USP54
VPS28
WWOX
YPEL3
YPEL5
ZMYND12
Entrez ID
7248
53358
HPRD ID
05594
12005
Ensembl ID
ENSG00000165699
ENSG00000148082
Uniprot IDs
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
Q92529
PDB IDs
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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