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TSC1 and HR
Data Source:
BioGRID
(two hybrid)
TSC1
HR
Description
TSC complex subunit 1
HR lysine demethylase and nuclear receptor corepressor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Histone Deacetylase Complex
Chromatin
Nucleoplasm
Molecular Function
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Transcription Coregulator Activity
Protein Binding
Oxidoreductase Activity
Chromatin DNA Binding
Histone Demethylase Activity (H3-K9 Specific)
Metal Ion Binding
Biological Process
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Regulation Of Transcription By RNA Polymerase II
Histone H3-K9 Demethylation
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
Atrichia with papular lesions
Localized autosomal recessive hypotrichosis
Marie-Unna hereditary hypotrichosis (MUHH)
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Obesity-related traits (
23251661
)
Interacting Genes
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
35 interacting genes:
AMMECR1
ATP23
C11orf1
C19orf54
CNFN
CYSRT1
FAM168A
GEMIN4
HDAC1
HDAC3
HDAC5
HMGB1
HOXA1
INCA1
KLHL20
KRTAP11-1
KRTAP13-2
KRTAP15-1
KRTAP3-1
KRTAP3-3
KRTAP6-3
MGAT5B
PLA2G10
PRKCA
RARA
RARB
RBP3
SPAG8
SPRY3
TBL1X
TRIM27
TSC1
VDR
YPEL3
ZMYND12
Entrez ID
7248
55806
HPRD ID
05594
03808
Ensembl ID
ENSG00000165699
ENSG00000168453
Uniprot IDs
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
O43593
PDB IDs
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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