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TSC1 and PITX1
Data Source:
BioGRID
(two hybrid)
TSC1
PITX1
Description
TSC complex subunit 1
paired like homeodomain 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Molecular Function
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Skeletal System Development
Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Morphogenesis
Branchiomeric Skeletal Muscle Development
Pituitary Gland Development
Embryonic Hindlimb Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Myoblast Fate Commitment
Cartilage Development
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
Congenital clubfoot; Congenital talipes equinovarus
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Atrial fibrillation (
29237688
)
Bulimia nervosa (
23568457
)
Colorectal cancer (
30529582
24836286
23263487
)
Colorectal cancer or advanced adenoma (
30510241
)
Height (
20881960
25429064
23563607
31562340
18391951
)
Immune response to anthrax vaccine (
22658931
)
Testicular germ cell tumor (
28604732
23666240
)
Interacting Genes
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
98 interacting genes:
ABHD11
AKAP8L
ALG13
ANKRD10
ARID5A
ATN1
BPIFA1
C10orf55
C11orf1
C19orf54
C1orf94
C9orf57
CDX4
CEACAM6
CYSRT1
DCTN3
DVL3
DZIP3
EFEMP2
EGR1
FAM168A
FAM168B
FOXO1
GATA1
GOLGA2
HGS
HOXA1
HSF4
HYI
IGFL2
IPO13
KLHL26
KRT34
KRT83
KRTAP13-1
KRTAP13-2
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP3-3
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
LASP1
LZTS2
MAGED1
METTL27
MGAT5B
MSX2
MYH7B
MYOZ3
NEUROD1
NHLRC4
NID2
NR5A1
PFDN5
PLA2G10
PLEKHB2
PLSCR1
PLSCR3
POU1F1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB11
PTK6
RBPMS
RFX6
RHOXF2
RNF31
ROR2
SERGEF
SERPINE1
SIK1B
SLC15A2
SMARCA2
SPAG8
STH
TBX19
TBX22
TEKT5
TFAP2D
TLE5
TP53BP1
TRAF1
TRAPPC2
TRIM23
TSC1
UFSP1
UPF2
VGLL3
YPEL3
ZBTB32
ZNF34
Entrez ID
7248
5307
HPRD ID
05594
03688
Ensembl ID
ENSG00000165699
ENSG00000069011
Uniprot IDs
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
P78337
X5D9A5
PDB IDs
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Intersection)
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