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MESD and IGF1
Data Source:
BioGRID
(two hybrid)
MESD
IGF1
Description
mesoderm development LRP chaperone
insulin like growth factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Extracellular Region
Extracellular Space
Insulin-like Growth Factor Binding Protein Complex
Platelet Alpha Granule Lumen
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Insulin-like Growth Factor Ternary Complex
Exocytic Vesicle
Molecular Function
Molecular_function
Protein Binding
Identical Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Biological Process
Ossification
Protein Folding
Phagocytosis
Mesoderm Development
Wnt Signaling Pathway
Protein Localization To Cell Surface
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Activation Of MAPK Activity
Skeletal System Development
Cell Activation
Platelet Degranulation
Signal Transduction
Ras Protein Signal Transduction
Muscle Organ Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Heat
Glycolate Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Muscle Hypertrophy
Myotube Cell Development
Positive Regulation Of Smooth Muscle Cell Migration
Proteoglycan Biosynthetic Process
Positive Regulation Of Cell Migration
Activation Of Protein Kinase B Activity
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Bone Mineralization Involved In Bone Maturation
Regulation Of Multicellular Organism Growth
Wound Healing
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Myoblast Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Positive Regulation Of Ras Protein Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Myoblast Proliferation
Negative Regulation Of Oocyte Development
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Trophectodermal Cell Proliferation
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Diseases
Malignant pleural mesothelioma
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Birth weight (
31043758
27680694
)
Brain morphology (MOSTest) (
32665545
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Fasting blood insulin (
20081858
22581228
)
Fasting blood insulin (BMI interaction) (
22581228
)
FEV1 (
30804560
)
Height (
25429064
19893584
31562340
31217584
20189936
)
Homeostasis model assessment of insulin resistance (
20081858
)
Insulin-related traits (multivariate analysis) (
32002517
)
Intraocular pressure (
29617998
29785010
)
Lung function (FVC) (
30804560
)
Mammographic density (dense area) (
25342443
)
Offspring birth weight (
31043758
)
Peak expiratory flow (
30804560
)
Refractive error (
32231278
)
Response to quetiapine in schizophrenia (
29503163
)
Systolic blood pressure (
30224653
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
75 interacting genes:
ABCG8
ABITRAM
ACBD7
ADAL
AKIRIN2
AKNAD1
AKT1
APP
ASH2L
ATP6V1E1
ATP6V1E2
BORCS8
BORCS8-MEF2B
BRD4
C17orf75
CCDC105
CDR2L
CENATAC
CENPH
CHCHD1
CLP1
CNOT9
COL10A1
COL1A2
COX14
COX5A
CUTC
CYP4F11
DDX6
ENKD1
FAM13C
FAM172A
FARS2
FCER1A
GEM
GOLGA7
GPKOW
GTPBP3
H2AB2
H2AB3
HSBP1L1
IGF1
KPNB1
LCE1A
LRP5
LY96
MAGEB4
MAP1LC3B
MCM9
MELTF
MKNK2
MRM1
MTNR1A
NRDE2
PMF1
PSMA5
QARS1
RCOR3
RFC3
SIK1B
SMARCB1
SNX5
SNX7
TEX12
TEX48
TPM2
TREX2
TRMT2A
TTC21A
TTC23
TYMP
UBQLN1
ZNF493
ZNF827
ZNF844
22 interacting genes:
BANP
CCN3
CCN5
CTSB
E2F1
ENKD1
IDE
IGF1R
IGFALS
IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7
IGSF1
MESD
MKRN3
SOX4
TCEANC
TF
Entrez ID
23184
3479
HPRD ID
12129
00936
Ensembl ID
ENSG00000117899
ENSG00000017427
Uniprot IDs
Q14696
P05019
Q13429
Q59GC5
Q5U743
PDB IDs
1B9G
1BQT
1GF1
1GZR
1GZY
1GZZ
1H02
1H59
1IMX
1PMX
1TGR
1WQJ
2DSP
2DSQ
2DSR
2GF1
3GF1
3LRI
4XSS
5U8Q
6FF3
6PYH
6RVA
Enriched GO Terms of Interacting Partners
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