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MESD and LY96
Data Source:
BioGRID
(two hybrid)
MESD
LY96
Description
mesoderm development LRP chaperone
lymphocyte antigen 96
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Extracellular Space
Plasma Membrane
Endosome Membrane
Intrinsic Component Of Plasma Membrane
Lipopolysaccharide Receptor Complex
Molecular Function
Molecular_function
Protein Binding
Identical Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Lipopolysaccharide Binding
Lipopolysaccharide Immune Receptor Activity
Protein Binding
Coreceptor Activity
Toll-like Receptor 4 Binding
Biological Process
Ossification
Protein Folding
Phagocytosis
Mesoderm Development
Wnt Signaling Pathway
Protein Localization To Cell Surface
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
Cellular Defense Response
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Response To Lipopolysaccharide
Detection Of Lipopolysaccharide
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Pathways
ER-Phagosome pathway
Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Morphine
(R)-3-hydroxytetradecanoic acid
Lauric acid
Myristic acid
Diseases
GWAS
Blood protein levels (
29875488
)
Carotid plaque burden (smoking interaction) (
24954085
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Postoperative atrial fibrillation in coronary artery bypass grafting surgery (
26385043
)
Interacting Genes
75 interacting genes:
ABCG8
ABITRAM
ACBD7
ADAL
AKIRIN2
AKNAD1
AKT1
APP
ASH2L
ATP6V1E1
ATP6V1E2
BORCS8
BORCS8-MEF2B
BRD4
C17orf75
CCDC105
CDR2L
CENATAC
CENPH
CHCHD1
CLP1
CNOT9
COL10A1
COL1A2
COX14
COX5A
CUTC
CYP4F11
DDX6
ENKD1
FAM13C
FAM172A
FARS2
FCER1A
GEM
GOLGA7
GPKOW
GTPBP3
H2AB2
H2AB3
HSBP1L1
IGF1
KPNB1
LCE1A
LRP5
LY96
MAGEB4
MAP1LC3B
MCM9
MELTF
MKNK2
MRM1
MTNR1A
NRDE2
PMF1
PSMA5
QARS1
RCOR3
RFC3
SIK1B
SMARCB1
SNX5
SNX7
TEX12
TEX48
TPM2
TREX2
TRMT2A
TTC21A
TTC23
TYMP
UBQLN1
ZNF493
ZNF827
ZNF844
8 interacting genes:
CALM1
CDKN2C
LCN2
MESD
MLH1
SMARCB1
TLR2
TLR4
Entrez ID
23184
23643
HPRD ID
12129
05579
Ensembl ID
ENSG00000117899
ENSG00000154589
Uniprot IDs
Q14696
Q9Y6Y9
PDB IDs
1T2Z
2E56
2E59
2Z65
3FXI
3ULA
4G8A
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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