IGF1 and IDE

Data Source:
HPRD (in vitro)

		IGF1	IDE
Description		insulin like growth factor 1	insulin degrading enzyme
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin-like Growth Factor Ternary Complex Exocytic Vesicle	Extracellular Space Nucleus Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytosolic Proteasome Complex Extracellular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity	Amyloid-beta Binding Virus Receptor Activity Endopeptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Beta-endorphin Binding Peptide Binding Protein Homodimerization Activity Insulin Binding Protein-containing Complex Binding Ubiquitin-dependent Protein Binding
	Biological Process	Activation Of MAPK Activity Skeletal System Development Cell Activation Platelet Degranulation Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Heat Glycolate Metabolic Process Regulation Of Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Proteoglycan Biosynthetic Process Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Smooth Muscle Cell Apoptotic Process Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Wound Healing Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Protein Kinase B Signaling Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Myoblast Proliferation Negative Regulation Of Oocyte Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Trophectodermal Cell Proliferation Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis Protein Targeting To Peroxisome Insulin Receptor Signaling Pathway Determination Of Adult Lifespan Bradykinin Catabolic Process Ubiquitin Recycling Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Catabolic Process Positive Regulation Of Protein Binding Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteolysis Viral Entry Into Host Cell Amyloid-beta Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Insulin Metabolic Process Insulin Catabolic Process Regulation Of Aerobic Respiration
Pathways		Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin	Ub-specific processing proteases Peroxisomal protein import Peroxisomal protein import
Drugs		N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate	Insulin pork Bacitracin
Diseases		Malignant pleural mesothelioma Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Birth weight ( 31043758 27680694) Brain morphology (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Fasting blood insulin ( 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Height ( 25429064 19893584 31562340 31217584 20189936) Homeostasis model assessment of insulin resistance ( 20081858) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Lung function (FVC) ( 30804560) Mammographic density (dense area) ( 25342443) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Response to quetiapine in schizophrenia ( 29503163) Systolic blood pressure ( 30224653) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Airflow obstruction ( 22837378) Asthma ( 31619474) Birth weight ( 31043758 27680694) Inflammatory bowel disease ( 28067908) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Triglyceride levels ( 32203549) Type 2 diabetes ( 22885922 24509480 29358691 30297969 26818947 32499647 20581827 30718926) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		22 interacting genes: BANP CCN3 CCN5 CTSB E2F1 ENKD1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 MESD MKRN3 SOX4 TCEANC TF	9 interacting genes: APP AR IGF1 IGF2 INS NR3C1 PEX5 UBC UCHL5
Entrez ID		3479	3416
HPRD ID		00936	00894
Ensembl ID		ENSG00000017427	ENSG00000119912
Uniprot IDs		P05019 Q13429 Q59GC5 Q5U743	A0A3B3ISG5 B3KSB8 P14735
PDB IDs		1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI 4XSS 5U8Q 6FF3 6PYH 6RVA	2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3
Enriched GO Terms of Interacting Partners?
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