MESD and RFC3

Data Source:
BioGRID (two hybrid)

		MESD	RFC3
Description		mesoderm development LRP chaperone	replication factor C subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding Low-density Lipoprotein Particle Receptor Binding	DNA Binding DNA Clamp Loader Activity Protein Binding ATPase Activity Single-stranded DNA Helicase Activity
	Biological Process	Ossification Protein Folding Phagocytosis Mesoderm Development Wnt Signaling Pathway Protein Localization To Cell Surface Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering	DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Response To Organophosphorus Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint
Drugs
Diseases
GWAS			Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)
Interacting Genes		75 interacting genes: ABCG8 ABITRAM ACBD7 ADAL AKIRIN2 AKNAD1 AKT1 APP ASH2L ATP6V1E1 ATP6V1E2 BORCS8 BORCS8-MEF2B BRD4 C17orf75 CCDC105 CDR2L CENATAC CENPH CHCHD1 CLP1 CNOT9 COL10A1 COL1A2 COX14 COX5A CUTC CYP4F11 DDX6 ENKD1 FAM13C FAM172A FARS2 FCER1A GEM GOLGA7 GPKOW GTPBP3 H2AB2 H2AB3 HSBP1L1 IGF1 KPNB1 LCE1A LRP5 LY96 MAGEB4 MAP1LC3B MCM9 MELTF MKNK2 MRM1 MTNR1A NRDE2 PMF1 PSMA5 QARS1 RCOR3 RFC3 SIK1B SMARCB1 SNX5 SNX7 TEX12 TEX48 TPM2 TREX2 TRMT2A TTC21A TTC23 TYMP UBQLN1 ZNF493 ZNF827 ZNF844	13 interacting genes: ANKRD40 ARFGAP1 CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4
Entrez ID		23184	5983
HPRD ID		12129	02676
Ensembl ID		ENSG00000117899	ENSG00000133119
Uniprot IDs		Q14696	A0A024RDQ8 P40938
PDB IDs			6VVO
Enriched GO Terms of Interacting Partners?
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