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MESD and LRP5
Data Source:
HPRD
(in vivo)
MESD
LRP5
Description
mesoderm development LRP chaperone
LDL receptor related protein 5
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Wnt-Frizzled-LRP5/6 Complex
Wnt Signalosome
Molecular Function
Molecular_function
Protein Binding
Identical Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Protein Binding
Coreceptor Activity
Wnt-protein Binding
Toxin Transmembrane Transporter Activity
Wnt-activated Receptor Activity
Coreceptor Activity Involved In Wnt Signaling Pathway
Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
Biological Process
Ossification
Protein Folding
Phagocytosis
Mesoderm Development
Wnt Signaling Pathway
Protein Localization To Cell Surface
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Gastrulation With Mouth Forming Second
Positive Regulation Of Mesenchymal Cell Proliferation
Osteoblast Development
Glucose Catabolic Process
Endocytosis
Cholesterol Metabolic Process
Regulation Of Blood Pressure
Positive Regulation Of Cell Population Proliferation
Response To Radiation
Anterior/posterior Pattern Specification
Positive Regulation Of Osteoblast Proliferation
Somatic Stem Cell Population Maintenance
Extracellular Matrix-cell Signaling
Cell Migration Involved In Gastrulation
Cholesterol Homeostasis
Embryonic Digit Morphogenesis
Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of Fat Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Bone Remodeling
Bone Marrow Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Anatomical Structure Regression
Retina Morphogenesis In Camera-type Eye
Canonical Wnt Signaling Pathway
Bone Morphogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Adipose Tissue Development
Cell-cell Signaling Involved In Mammary Gland Development
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Retinal Blood Vessel Morphogenesis
Negative Regulation Of Protein Serine/threonine Kinase Activity
Norrin Signaling Pathway
Toxin Transport
Apoptotic Process Involved In Blood Vessel Morphogenesis
Pathways
TCF dependent signaling in response to WNT
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
Signaling by LRP5 mutants
Signaling by RNF43 mutants
Drugs
Diseases
Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
Osteoporosis-pseudoglioma syndrome (OPPG)
Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetrosis, autosomal dominant 1 (OPTA1)
GWAS
Bone mineral density (
24249740
18455228
)
Bone mineral density (paediatric, skull) (
24945404
)
Bone mineral density (paediatric, total body less head) (
28743860
)
Bone mineral density (spine) (
19801982
)
Femoral neck bone mineral density (
29499414
)
Femoral neck section modulus (
30888730
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
Lumbar spine bone mineral density (
29499414
22504420
)
Medication use (drugs affecting bone structure and mineralization) (
31015401
)
Monobrow (
27182965
)
Interacting Genes
75 interacting genes:
ABCG8
ABITRAM
ACBD7
ADAL
AKIRIN2
AKNAD1
AKT1
APP
ASH2L
ATP6V1E1
ATP6V1E2
BORCS8
BORCS8-MEF2B
BRD4
C17orf75
CCDC105
CDR2L
CENATAC
CENPH
CHCHD1
CLP1
CNOT9
COL10A1
COL1A2
COX14
COX5A
CUTC
CYP4F11
DDX6
ENKD1
FAM13C
FAM172A
FARS2
FCER1A
GEM
GOLGA7
GPKOW
GTPBP3
H2AB2
H2AB3
HSBP1L1
IGF1
KPNB1
LCE1A
LRP5
LY96
MAGEB4
MAP1LC3B
MCM9
MELTF
MKNK2
MRM1
MTNR1A
NRDE2
PMF1
PSMA5
QARS1
RCOR3
RFC3
SIK1B
SMARCB1
SNX5
SNX7
TEX12
TEX48
TPM2
TREX2
TRMT2A
TTC21A
TTC23
TYMP
UBQLN1
ZNF493
ZNF827
ZNF844
9 interacting genes:
AXIN1
CAPRIN2
DKK1
FZD8
MESD
MTDH
SMAD9
THBS1
WNT1
Entrez ID
23184
4041
HPRD ID
12129
04616
Ensembl ID
ENSG00000117899
ENSG00000162337
Uniprot IDs
Q14696
O75197
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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