SPART and EPN2

Data Source:
BioGRID (two hybrid)

		SPART	EPN2
Description		spartin	epsin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding
	Biological Process	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547)
Interacting Genes		22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9	40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		23111	22905
HPRD ID		06170	06271
Ensembl ID		ENSG00000133104	ENSG00000072134
Uniprot IDs		A0A024RDV9 Q8N0X7	O95208
PDB IDs		2DL1 4U7I
Enriched GO Terms of Interacting Partners?
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