SPART and OTUB2

Data Source:
BioGRID (two hybrid)

		SPART	OTUB2
Description		spartin	OTU deubiquitinase, ubiquitin aldehyde binding 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse	Nucleus
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development	Protein Deubiquitination Protein Phosphopantetheinylation Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways			Ovarian tumor domain proteases
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9	42 interacting genes: APP ARRDC3 CDIP1 CPSF6 DAZAP2 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 MKRN1 PHLDA2 PJA1 PLEKHB2 PMEPA1 RBCK1 REL RFFL RNF126 SIAH1 SPART TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28
Entrez ID		23111	78990
HPRD ID		06170	07620
Ensembl ID		ENSG00000133104	ENSG00000089723
Uniprot IDs		A0A024RDV9 Q8N0X7	Q96DC9
PDB IDs		2DL1 4U7I	1TFF 4FJV 5QIO 5QIP 5QIQ 5QIR 5QIS 5QIT 5QIU 5QIV 5QIW 5QIX 5QIY 5QIZ
Enriched GO Terms of Interacting Partners?
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