MTF2 and SUV39H2

Data Source:
BioGRID (two hybrid)

		MTF2	SUV39H2
Description		metal response element binding transcription factor 2	suppressor of variegation 3-9 homolog 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion ESC/E(Z) Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Corepressor Binding DNA Binding Chromatin Binding Methylated Histone Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Segment Specification Stem Cell Population Maintenance Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways		PRC2 methylates histones and DNA	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Plasma clusterin levels ( 26545630) Response to lurasidone in schizophrenia ( 29730043) Triglyceride levels ( 32154731)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		12 interacting genes: CDKN2D CREB1 GPRASP1 GSK3B KDM1A PIK3R3 PRKD2 PRMT6 SMAD3 SUV39H1 SUV39H2 TMED9	41 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		22823	79723
HPRD ID		14342	07580
Ensembl ID		ENSG00000143033	ENSG00000152455
Uniprot IDs		B4DZ69 B4DZG1 Q7Z534 Q9Y483	Q9H5I1
PDB IDs		5XFR	2R3A 6P0R
Enriched GO Terms of Interacting Partners?
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