SUV39H2 and PHF19

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SUV39H2	PHF19
Description		suppressor of variegation 3-9 homolog 2	PHD finger protein 19
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) S-adenosyl-L-methionine Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia	Chromatin Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K27 Methylation
Pathways		PKMTs methylate histone lysines	PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758 27680694) Corneal astigmatism ( 29422769) High density lipoprotein cholesterol levels ( 29403010) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 28135244 27618448) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57	21 interacting genes: BAG4 CSNK2A1 DVL3 H3C1 HOMEZ HOXB5 INO80E KDM1A LZTS2 PICK1 POTEB3 RCOR3 SNIP1 SUV39H1 SUV39H2 THAP1 THAP7 TSPYL2 YTHDC1 ZNF837 ZRANB1
Entrez ID		79723	26147
HPRD ID		07580	17846
Ensembl ID		ENSG00000152455	ENSG00000119403
Uniprot IDs		Q9H5I1	A0A087X169 B7Z887 B7Z8H3 F5H8K3 Q5T6S3
PDB IDs		2R3A 6P0R	2E5Q 4BD3 6NQ3 6WAU
Enriched GO Terms of Interacting Partners?
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