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SUV39H2 and SHC1
Data Source:
BioGRID
(two hybrid)
SUV39H2
SHC1
Description
suppressor of variegation 3-9 homolog 2
SHC adaptor protein 1
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Chromatin
Nucleus
Nucleoplasm
Mitochondrial Matrix
Cytosol
Plasma Membrane
Shc-EGFR Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Zinc Ion Binding
Histone Methyltransferase Activity (H3-K9 Specific)
S-adenosyl-L-methionine Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Assembly Or Disassembly
Chromatin Remodeling
Cell Cycle
Cell Differentiation
Histone Lysine Methylation
Histone H3-K9 Dimethylation
Histone H3-K9 Trimethylation
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Cellular Response To Hypoxia
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Ras Protein Signal Transduction
Axon Guidance
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Reorganization
Interleukin-15-mediated Signaling Pathway
IRE1-mediated Unfolded Protein Response
Fc-epsilon Receptor Signaling Pathway
Interleukin-2-mediated Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of Growth
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Ras Protein Signal Transduction
Leukocyte Migration
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cell-cell Adhesion
Pathways
PKMTs methylate histone lysines
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil counts (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Interacting Genes
41 interacting genes:
AKAP9
APPL2
AR
BLZF1
C8orf74
CBX7
CDCA4
CEP70
CFAP100
CGGBP1
EWSR1
FAM20C
GOLGA6L9
GSTCD
ID2
KCTD17
KLF3
KLHDC4
LCA5L
LNX1
LRIF1
MAGEA11
MCM3AP
MRFAP1
MTF2
MYL12A
NME4
ODAD3
PHF19
PNMA1
POLR3F
RAB3IP
RASSF1
SHC1
SMAD5
SNF8
UBE2V2
WIZ
ZNF212
ZNF557
ZNF57
143 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
Entrez ID
79723
6464
HPRD ID
07580
02780
Ensembl ID
ENSG00000152455
ENSG00000160691
Uniprot IDs
Q9H5I1
P29353
PDB IDs
2R3A
6P0R
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
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