PHACTR1 and ACTA1

Data Source:
HPRD (in vivo)

		PHACTR1	ACTA1
Description		phosphatase and actin regulator 1	actin alpha 1, skeletal muscle
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Synapse	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Cerebral Cortex Development Actin Cytoskeleton Organization Actomyosin Structure Organization Actin Cytoskeleton Reorganization Negative Regulation Of Phosphoprotein Phosphatase Activity Stress Fiber Assembly Cell Motility Dendrite Arborization Regulation Of Neuron Migration	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258 30679032) Basophil percentage of white cells ( 32888494) Blood pressure ( 22763476) Cervical artery dissection ( 25420145) Chronotype ( 30696823 26835600) Coronary artery calcification ( 22144573 23394302) Coronary artery disease ( 32469254 29212778 24262325 30104761 26343387 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22745674 21846871 22751097 21378988 21378990) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diastolic blood pressure ( 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gait speed in old age ( 28077804) Hand grip strength ( 29691431) Headache ( 29397368) Hip geometry ( 17903296) HIV-1 viral setpoint ( 26039976) Hypertension ( 27618447) Idiopathic dilated cardiomyopathy ( 29495422) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Morning person ( 30696823) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Pulse pressure ( 28135244 27841878 27618447 30578418) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Spontaneous coronary artery dissection ( 32887874 32374345) Systolic blood pressure ( 27841878 27618447 30578418)
Interacting Genes		5 interacting genes: ACTA1 C14orf119 CBX8 LINC00839 PPP1CA	114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		221692	58
HPRD ID		12283	00030
Ensembl ID		ENSG00000112137	ENSG00000143632
Uniprot IDs		A0A6Q8PFA8 A0A6Q8PG87 B4DHU0 Q9C0D0	P68133
PDB IDs		6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ
Enriched GO Terms of Interacting Partners?
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