PHACTR1 and CBX8

Data Source:
BioGRID (two hybrid)

		PHACTR1	CBX8
Description		phosphatase and actin regulator 1	chromobox 8
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GO Annotations	Cellular Component	Nucleus Cytosol Synapse	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Cerebral Cortex Development Actin Cytoskeleton Organization Actomyosin Structure Organization Actin Cytoskeleton Reorganization Negative Regulation Of Phosphoprotein Phosphatase Activity Stress Fiber Assembly Cell Motility Dendrite Arborization Regulation Of Neuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258 30679032) Basophil percentage of white cells ( 32888494) Blood pressure ( 22763476) Cervical artery dissection ( 25420145) Chronotype ( 30696823 26835600) Coronary artery calcification ( 22144573 23394302) Coronary artery disease ( 32469254 29212778 24262325 30104761 26343387 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22745674 21846871 22751097 21378988 21378990) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diastolic blood pressure ( 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gait speed in old age ( 28077804) Hand grip strength ( 29691431) Headache ( 29397368) Hip geometry ( 17903296) HIV-1 viral setpoint ( 26039976) Hypertension ( 27618447) Idiopathic dilated cardiomyopathy ( 29495422) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Morning person ( 30696823) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Pulse pressure ( 28135244 27841878 27618447 30578418) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Spontaneous coronary artery dissection ( 32887874 32374345) Systolic blood pressure ( 27841878 27618447 30578418)	Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: ACTA1 C14orf119 CBX8 LINC00839 PPP1CA	87 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-4 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RPGRIP1 SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1
Entrez ID		221692	57332
HPRD ID		12283	13006
Ensembl ID		ENSG00000112137	ENSG00000141570
Uniprot IDs		A0A6Q8PFA8 A0A6Q8PG87 B4DHU0 Q9C0D0	Q9HC52
PDB IDs		6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ	2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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