ETV6 and CRKL

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		ETV6	CRKL
Description		ETS variant transcription factor 6	CRK like proto-oncogene, adaptor protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleolus Cytosol	Nucleoplasm Cytosol Neuromuscular Junction Protein-containing Complex Extrinsic Component Of Postsynaptic Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding	Phosphotyrosine Residue Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process	Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Lipid Metabolic Process JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Synapse Assembly Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Helper T Cell Diapedesis Cellular Response To Drug Reelin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Pharynx Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Acetylcholine Receptor Signaling Pathway Cerebellar Neuron Development Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration
Pathways		Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Height ( 28552196 20881960 25282103 23563607 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)	Mean platelet volume ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		17 interacting genes: AP1M1 AXIN1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NTAQ1 PIN1 SIN3A SMURF1 SUMO1 TRAF2 UBE2I	79 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RIN3 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1
Entrez ID		2120	1399
HPRD ID		15976	03596
Ensembl ID		ENSG00000139083	ENSG00000099942
Uniprot IDs		A0A0S2Z3C9 P41212	P46109
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?
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