ETV6 and FBXL6

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ETV6	FBXL6
Description		ETS variant transcription factor 6	F-box and leucine rich repeat protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleolus Cytosol	Nucleus Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Proteolysis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle
Pathways		Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Asthma ( 27611488) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Height ( 28552196 20881960 25282103 23563607 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010) Red blood cell count ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		17 interacting genes: AP1M1 AXIN1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NTAQ1 PIN1 SIN3A SMURF1 SUMO1 TRAF2 UBE2I	3 interacting genes: ETV6 SKP1 TSC2
Entrez ID		2120	26233
HPRD ID		15976	16429
Ensembl ID		ENSG00000139083	ENSG00000182325
Uniprot IDs		A0A0S2Z3C9 P41212	Q8N531
PDB IDs		1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P
Enriched GO Terms of Interacting Partners?
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