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GNB3 and GNG12
Data Source:
BioGRID
(affinity chromatography technology, fluorescent resonance energy transfer)
GNB3
GNG12
Description
G protein subunit beta 3
G protein subunit gamma 12
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Heterotrimeric G-protein Complex
Plasma Membrane
Dendrite
Cell Body
Extracellular Exosome
Heterotrimeric G-protein Complex
Actin Filament
Plasma Membrane
G-protein Beta/gamma-subunit Complex
Extracellular Exosome
Molecular Function
GTPase Activity
Protein Binding
Spectrin Binding
G-protein Gamma-subunit Binding
GTPase Binding
Protein Binding
PDZ Domain Binding
G-protein Beta-subunit Binding
Phosphate Ion Binding
Biological Process
Protein Folding
Cell Volume Homeostasis
G Protein-coupled Receptor Signaling Pathway
Regulation Of Blood Pressure
Regulation Of Gene Expression
Regulation Of Glucose Metabolic Process
Regulation Of Hormone Metabolic Process
Regulation Of Fat Cell Differentiation
Regulation Of Feeding Behavior
Regulation Of Cholesterol Metabolic Process
Regulation Of Triglyceride Metabolic Process
Regulation Of Locomotion Involved In Locomotory Behavior
Regulation Of Phospholipid Metabolic Process
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Cerebral Cortex Development
Response To Lipopolysaccharide
Pathways
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS
Central retinal vein equivalent (
26567291
)
High myopia (
31816047
)
Macular thickness (
30535121
)
Myopia (
27182965
)
Refractive error (
32231278
)
Response to Vitamin E supplementation (
22437554
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Feeling fed-up (
29500382
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Red cell distribution width (
32888494
)
Thyroid stimulating hormone levels (
32769997
)
Upper eyelid morphology (
29921221
)
Interacting Genes
13 interacting genes:
CIDEB
GNG10
GNG12
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GRK2
RASD2
TGFBR1
7 interacting genes:
CAPN1
FHL2
GNB1
GNB2
GNB3
GNB4
HDAC7
Entrez ID
2784
55970
HPRD ID
00743
13592
Ensembl ID
ENSG00000111664
ENSG00000172380
Uniprot IDs
E9PCP0
F1T0G5
P16520
Q9UBI6
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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