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COMMD1 and NFKBIA
Data Source:
HPRD
(in vivo)
COMMD1
NFKBIA
Description
copper metabolism domain containing 1
NFKB inhibitor alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Endosome Membrane
Cul2-RING Ubiquitin Ligase Complex
Recycling Endosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Molecular Function
Copper Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Sodium Channel Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
Phosphatidylinositol-3,4-bisphosphate Binding
Phosphatidic Acid Binding
Phosphatidylinositol-3,5-bisphosphate Binding
Protein Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Biological Process
Nucleotide-excision Repair
Golgi To Plasma Membrane Transport
Protein Transport
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Plasma Membrane To Endosome Transport
Copper Ion Homeostasis
Negative Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Protein Localization To Cell Surface
Protein Import Into Nucleus
Apoptotic Process
I-kappaB Kinase/NF-kappaB Signaling
Cytoplasmic Sequestering Of NF-kappaB
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Lipid Storage
Viral Process
Protein Deubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Response To Muramyl Dipeptide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Negative Regulation Of DNA Binding
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Regulation Of NIK/NF-kappaB Signaling
Pathways
Neddylation
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Hodgkin lymphoma
GWAS
Age-related nuclear cataracts (
33311586
)
Erectile dysfunction (
30583798
)
Height (
31562340
)
Iron status biomarkers (total iron binding capacity) (
28334935
)
Mean corpuscular volume (
27863252
)
Nonalcoholic fatty liver disease (
31311600
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
PR interval (
32439900
)
Psoriasis (
25854761
25903422
20953189
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
28739976
30578418
)
White blood cell count (
32888494
)
Interacting Genes
31 interacting genes:
BAHCC1
BARD1
BRCA1
COMMD10
COMMD2
COMMD3
COMMD4
COMMD5
COMMD6
COMMD7
COMMD8
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
ELOC
KAT2A
LIG4
NFKBIA
PRKN
RELA
SLC12A2
SOCS1
SOD1
SPP1
TCEAL8
UPRT
XIAP
89 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
VCP
ZNF212
Entrez ID
150684
4792
HPRD ID
06253
01235
Ensembl ID
ENSG00000173163
ENSG00000100906
Uniprot IDs
Q8N668
P25963
PDB IDs
2H2M
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
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