COMMD1 and SLC12A2

Data Source:
BioGRID (two hybrid, pull down)

		COMMD1	SLC12A2
Description		copper metabolism domain containing 1	solute carrier family 12 member 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Cell Projection Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Cell Body Membrane Extracellular Exosome Cell Periphery Spanning Component Of Membrane Extracellular Vesicle
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Cation:chloride Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Metal Ion Transmembrane Transporter Activity Chaperone Binding Hsp90 Protein Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface	Ion Transport Cellular Sodium Ion Homeostasis Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Aging T Cell Chemotaxis Ammonium Transport Cellular Potassium Ion Homeostasis Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis Maintenance Of Blood-brain Barrier Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Negative Regulation Of Vascular Wound Healing Transepithelial Ammonium Transport Ammonium Transmembrane Transport Inorganic Anion Import Across Plasma Membrane Inorganic Cation Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Chloride Transmembrane Transport Positive Regulation Of Aspartate Secretion Regulation Of Matrix Metallopeptidase Secretion Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine
Pathways		Neddylation	Cation-coupled Chloride cotransporters
Drugs			Torasemide Potassium chloride Bumetanide Quinethazone
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Apolipoprotein A1 levels ( 32203549) Beard thickness ( 26926045) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) HDL cholesterol levels ( 32203549) Height ( 25282103 31562340) Ileal carcinoids ( 21139019) Immature fraction of reticulocytes ( 32888494) Pelvic organ prolapse ( 32184442) Red cell distribution width ( 28957414) Statin-induced myopathy ( 31220337)
Interacting Genes		31 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT XIAP	3 interacting genes: COMMD1 OXSR1 STK39
Entrez ID		150684	6558
HPRD ID		06253	06775
Ensembl ID		ENSG00000173163	ENSG00000064651
Uniprot IDs		Q8N668	B7ZM24 P55011 Q53ZR1
PDB IDs		2H2M	6PZT
Enriched GO Terms of Interacting Partners?
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