COMMD1 and COMMD7

Data Source:
HPRD (in vitro)

		COMMD1	COMMD7
Description		copper metabolism domain containing 1	COMM domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Cytoplasmic Vesicle
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding NF-kappaB Binding
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface	Negative Regulation Of NF-kappaB Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		Neddylation	Neddylation
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Arterial stiffness index ( 31235810) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Metabolite levels ( 23823483) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 25760438) White blood cell count (basophil) ( 29403010)
Interacting Genes		31 interacting genes: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT XIAP	2 interacting genes: CHRM3 COMMD1
Entrez ID		150684	149951
HPRD ID		06253	13085
Ensembl ID		ENSG00000173163	ENSG00000149600
Uniprot IDs		Q8N668	Q86VX2
PDB IDs		2H2M
Enriched GO Terms of Interacting Partners?
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