NOTCH2 and LFNG

Data Source:
HPRD (in vitro, in vivo)

		NOTCH2	LFNG
Description		notch receptor 2	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex	Extracellular Region Integral Component Of Golgi Membrane Extracellular Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity NF-kappaB Binding	Acetylglucosaminyltransferase Activity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Heart Looping Morphogenesis Of An Epithelial Sheet Marginal Zone B Cell Differentiation Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Multicellular Organism Development Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Stem Cell Population Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intrahepatic Bile Duct Development Wound Healing Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Growth Rate Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Proximal Tubule Development Glomerular Visceral Epithelial Cell Development Glomerular Capillary Formation Hepatocyte Proliferation Cholangiocyte Proliferation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Osteoclast Development	Somitogenesis Marginal Zone B Cell Differentiation Regulation Of Notch Signaling Pathway Animal Organ Morphogenesis Regulation Of Somitogenesis T Cell Differentiation Negative Regulation Of Notch Signaling Pathway Involved In Somitogenesis
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription	Pre-NOTCH Processing in Golgi Defective LFNG causes SCDO3
Drugs
Diseases		Alagille syndrome Type II diabetes mellitus Hajdu-Cheney syndrome	Spondylocostal dysostosis (SCD)
GWAS		Blood protein levels ( 30072576) Hepatocyte growth factor levels ( 25998175) Nevus count or cutaneous melanoma ( 32341527) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 18372903 30054458 30297969)	Diastolic blood pressure ( 28739976 27618452) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Systolic blood pressure ( 27618452)
Interacting Genes		31 interacting genes: ANKRD28 CCR2 CNTN1 CRKL CST6 DLL1 DTX1 DTX3 EGFL7 EPSTI1 GSK3B IL13RA2 IL24 ITIH5 JAG1 JAG2 KLK5 LFNG LRATD2 MAML1 MAML2 MAML3 MFNG MTA3 MYOC PSEN1 PSEN2 PSMC3IP RBPJ SMAD1 ST14	3 interacting genes: APP NOTCH1 NOTCH2
Entrez ID		4853	3955
HPRD ID		02606	03987
Ensembl ID		ENSG00000134250	ENSG00000106003
Uniprot IDs		Q04721 Q6IQ50 Q9UFD5	Q8NES3
PDB IDs		2OO4 5MWB
Enriched GO Terms of Interacting Partners?
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