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NOTCH2 and CCR2
Data Source:
BioGRID
(two hybrid)
NOTCH2
CCR2
Description
notch receptor 2
C-C motif chemokine receptor 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Cell Surface
Membrane
Receptor Complex
Cytoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Dendrite
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
Calcium Ion Binding
Protein Binding
Enzyme Binding
Signaling Receptor Activity
NF-kappaB Binding
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
CCR2 Chemokine Receptor Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Heart Looping
Morphogenesis Of An Epithelial Sheet
Marginal Zone B Cell Differentiation
Inflammatory Response To Antigenic Stimulus
Pulmonary Valve Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Humoral Immune Response
Cell Cycle Arrest
Notch Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Positive Regulation Of Keratinocyte Proliferation
Stem Cell Population Maintenance
Hemopoiesis
Embryonic Limb Morphogenesis
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intrahepatic Bile Duct Development
Wound Healing
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Growth Rate
Positive Regulation Of Ras Protein Signal Transduction
Bone Remodeling
Atrial Septum Morphogenesis
Placenta Blood Vessel Development
Ciliary Body Morphogenesis
Notch Signaling Involved In Heart Development
Positive Regulation Of ERK1 And ERK2 Cascade
Left/right Axis Specification
Proximal Tubule Development
Glomerular Visceral Epithelial Cell Development
Glomerular Capillary Formation
Hepatocyte Proliferation
Cholangiocyte Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Osteoclast Development
Blood Vessel Remodeling
Dendritic Cell Chemotaxis
Regulation Of T Cell Cytokine Production
Positive Regulation Of T-helper 1 Type Immune Response
Negative Regulation Of Type 2 Immune Response
Cellular Calcium Ion Homeostasis
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Receptor Signaling Pathway Via JAK-STAT
Response To Wounding
Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of T Cell Chemotaxis
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Calcium-mediated Signaling
Cellular Homeostasis
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Monocyte Extravasation
T-helper 17 Cell Chemotaxis
Negative Regulation Of Eosinophil Degranulation
Regulation Of T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of T Cell Activation
Positive Regulation Of Synaptic Transmission, Glutamatergic
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages
Inflammatory Response To Wounding
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of NMDA Glutamate Receptor Activity
Macrophage Migration
Positive Regulation Of Thymocyte Migration
Positive Regulation Of Monocyte Extravasation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation
Positive Regulation Of Astrocyte Chemotaxis
Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 Activation and Transmission of Signal to the Nucleus
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
INCB3284
CCX915
Plozalizumab
Diseases
Alagille syndrome
Type II diabetes mellitus
Hajdu-Cheney syndrome
GWAS
Blood protein levels (
30072576
)
Hepatocyte growth factor levels (
25998175
)
Nevus count or cutaneous melanoma (
32341527
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
18372903
30054458
30297969
)
Blood protein levels (
28240269
23696881
)
Celiac disease (
22057235
20190752
25920553
24999842
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
29403010
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Obesity-related traits (
23251661
)
Rheumatoid arthritis (
32868391
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
31 interacting genes:
ANKRD28
CCR2
CNTN1
CRKL
CST6
DLL1
DTX1
DTX3
EGFL7
EPSTI1
GSK3B
IL13RA2
IL24
ITIH5
JAG1
JAG2
KLK5
LFNG
LRATD2
MAML1
MAML2
MAML3
MFNG
MTA3
MYOC
PSEN1
PSEN2
PSMC3IP
RBPJ
SMAD1
ST14
40 interacting genes:
APP
ARL6IP5
ATP2B1
B3GAT3
BLOC1S6
CACYBP
CD59
CD81
CDIP1
CLPTM1
DMWD
EMC10
ERGIC3
GOT1
GPR161
HERPUD1
HMOX2
JPH3
NDFIP1
NOTCH2
NTNG2
PCMT1
PLLP
PTPN9
RGR
RHOG
RTN3
S1PR5
SCG5
SLC2A1
SLC41A3
SRSF5
SUMO1
SVOP
TECPR2
TMEM161A
TMEM199
TMEM63A
TSPAN7
WLS
Entrez ID
4853
729230
HPRD ID
02606
19667
Ensembl ID
ENSG00000134250
ENSG00000121807
Uniprot IDs
Q04721
Q6IQ50
Q9UFD5
A0A024R2Q0
P41597
PDB IDs
2OO4
5MWB
1KAD
1KP1
2MLO
2MLQ
5T1A
Enriched GO Terms of Interacting Partners
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