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AHNAK2 and IGFBP5
Data Source:
BioGRID
(two hybrid)
AHNAK2
IGFBP5
Description
AHNAK nucleoprotein 2
insulin like growth factor binding protein 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Z Disc
T-tubule
Cytoplasmic Vesicle Membrane
Sarcolemma
Costamere
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Insulin-like Growth Factor Binding Protein Complex
Insulin-like Growth Factor Ternary Complex
Molecular Function
Protein Binding
Fibronectin Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Biological Process
Plasma Membrane Repair
Regulation Of RNA Splicing
Regulation Of Cell Growth
Osteoblast Differentiation
Signal Transduction
Female Pregnancy
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Negative Regulation Of Translation
Negative Regulation Of Cell Migration
Hair Follicle Morphogenesis
Intracellular Signal Transduction
Glucose Homeostasis
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Post-translational Protein Modification
Cellular Protein Metabolic Process
Type B Pancreatic Cell Proliferation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Growth
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Involution
Response To Growth Hormone
Cellular Response To CAMP
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Muscle Tissue Development
Negative Regulation Of Skeletal Muscle Hypertrophy
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
GWAS
Cerebrospinal fluid t-tau levels (
29274321
)
Cerebrospinal fluid t-tau levels in normal cognition (
29274321
)
Rheumatoid arthritis (
30423114
24390342
)
Systemic lupus erythematosus (
26663301
)
Blood protein levels (
30072576
29875488
)
Breast cancer (
29059683
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
FEV1 (
30804560
)
Glomerular filtration rate (
27588450
29403010
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Height (
31562340
)
Hypothyroidism (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Metabolite levels (
23823483
)
Mitral valve prolapse (
26301497
)
Pulse pressure (
27841878
)
Serum thyroid-stimulating hormone levels (
25436638
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Visceral fat (
22589738
)
Interacting Genes
16 interacting genes:
ABLIM2
ASGR1
C3orf52
CTSA
CYB5B
CYBC1
FAM3C
GABARAPL1
GABARAPL2
IGFBP5
PRAP1
SUMO2
TSPO2
UBIAD1
VAMP3
ZFPL1
92 interacting genes:
ABHD4
ADAM12
AHNAK2
AMIGO1
ANKS6
APH1A
AQP2
AQP6
AQP9
ASGR1
BAG6
BSND
CD53
CERS4
CHODL
CLDN2
CLDN20
CLDN6
CLDN7
CLDN9
CLEC17A
CREB3
CXCR1
ELOVL5
ERGIC3
F2
FAM209A
FCRL3
FHL1
FHL2
FN1
FNDC9
GJA5
GJA8
GJB3
GJB5
GOLM1
GPR151
GPR152
GPR37L1
GPR42
GPRC5D
GPX8
HSD17B13
IGF1
IGF2
IGFALS
KCNK5
KIAA2013
KPNB1
LAPTM4B
LAYN
LDLRAD1
LHFPL1
LMNA
LTBP1
MFF
MFSD5
MRPS18B
MS4A3
MS4A7
NCAPH2
PAPPA2
PDZK1IP1
PNO1
PROKR2
RASSF1
RHCG
SERPINE1
SLC10A6
SLC13A4
SLC38A1
SLC41A2
SLC41A3
SPAG4
SPP1
SYNE4
TF
THAP4
THBS1
TLCD4
TMEM106A
TMEM106C
TMEM179B
TMEM237
TMEM45A
TMEM52B
TMPRSS2
TMX2
TSPAN12
TSPO2
VTN
Entrez ID
113146
3488
HPRD ID
12261
00901
Ensembl ID
ENSG00000185567
ENSG00000115461
Uniprot IDs
Q8IVF2
P24593
PDB IDs
4CN0
1BOE
1H59
Enriched GO Terms of Interacting Partners
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