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YWHAQ and TP53BP2
Data Source:
BioGRID
(pull down)
YWHAQ
TP53BP2
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
tumor protein p53 binding protein 2
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Protein-containing Complex
Synapse
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Identical Protein Binding
Ion Channel Binding
Protein N-terminus Binding
14-3-3 Protein Binding
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Biological Process
Protein Targeting
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Heart rate variability traits (
22174390
)
Non-response to selective serotonin reuptake inhibitors and depression (
27622933
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
240 interacting genes:
AARS2
ABL1
ACSL4
ADRB2
AGTR1
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ARHGEF2
ATP5F1A
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EGFR
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1
H2BC8
H4C14
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HSPB1
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
ITPRID2
KANK1
KCNK15
KCNK3
KCNK9
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SOCS3
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSX2IP
SUMO2
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRAF6
TRIM25
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBE2L3
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS1
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
122 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC85A
CCDC92
CDC5L
CEP55
CEP95
CGN
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KDM1A
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NDC80
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RASSF8
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
YWHAQ
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
Entrez ID
10971
7159
HPRD ID
00886
11803
Ensembl ID
ENSG00000134308
ENSG00000143514
Uniprot IDs
P27348
Q13625
PDB IDs
2BTP
5IQP
6BCR
6BD2
6BQT
6KZG
6KZH
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
Enriched GO Terms of Interacting Partners
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