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YWHAQ and ADRB2
Data Source:
BioGRID
(two hybrid)
YWHAQ
ADRB2
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
adrenoceptor beta 2
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Protein-containing Complex
Synapse
Extracellular Exosome
Nucleus
Lysosome
Endosome
Early Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Endosome Membrane
Membrane
Apical Plasma Membrane
Clathrin-coated Vesicle Membrane
Receptor Complex
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Identical Protein Binding
Ion Channel Binding
Protein N-terminus Binding
14-3-3 Protein Binding
Amyloid-beta Binding
G Protein-coupled Receptor Activity
Beta2-adrenergic Receptor Activity
Protein Binding
Adenylate Cyclase Binding
Potassium Channel Regulator Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Norepinephrine Binding
Biological Process
Protein Targeting
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Diet Induced Thermogenesis
Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Sodium Ion Transport
Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin
Receptor-mediated Endocytosis
Cell Surface Receptor Signaling Pathway
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Endosome To Lysosome Transport
Response To Cold
Positive Regulation Of Protein Kinase A Signaling
Protein Deubiquitination
Positive Regulation Of Bone Mineralization
Heat Generation
Negative Regulation Of Multicellular Organism Growth
Positive Regulation Of MAPK Cascade
Bone Resorption
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Smooth Muscle Contraction
Brown Fat Cell Differentiation
Membrane Organization
Positive Regulation Of Mini Excitatory Postsynaptic Potential
Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Autophagosome Maturation
Positive Regulation Of Lipophagy
Cellular Response To Amyloid-beta
Response To Psychosocial Stress
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of AMPA Receptor Activity
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Adrenoceptors
G alpha (s) signalling events
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Phenethyl Isothiocyanate
Spermine
Amphetamine
Betaxolol
Bethanidine
Isoetharine
Cabergoline
Metoprolol
Olanzapine
Atenolol
Norepinephrine
Timolol
Phenylpropanolamine
Dipivefrin
Sotalol
Carteolol
Nortriptyline
Propranolol
Labetalol
Bisoprolol
Epinephrine
Paroxetine
Trimipramine
Cryptenamine
Orciprenaline
Dobutamine
Pseudoephedrine
Alprenolol
Ritodrine
Terbutaline
Bitolterol
Phenoxybenzamine
Salmeterol
Pindolol
Formoterol
Salbutamol
Ergoloid mesylate
Isoprenaline
Arbutamine
Amiodarone
Carvedilol
Desipramine
Propafenone
Acebutolol
Nadolol
Levobunolol
Metipranolol
Aripiprazole
Arformoterol
Fenoterol
Pirbuterol
Bevantolol
Penbutolol
Ephedra sinica root
Ephedrine
Mephentermine
Procaterol
Clenbuterol
Bambuterol
Oxprenolol
Putrescine
Spermidine
Celiprolol
Nebivolol
Indacaterol
Bedoradrine
NCX 950
Asenapine
Droxidopa
Bufuralol
Protokylol
(S)-carazolol
Bopindolol
Bupranolol
Befunolol
Olodaterol
Vilanterol
Arotinolol
Doxofylline
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Etafedrine
Tulobuterol
Levosalbutamol
Dihydroergocristine
Diseases
Asthma
GWAS
Heart rate variability traits (
22174390
)
Non-response to selective serotonin reuptake inhibitors and depression (
27622933
)
Chronic obstructive pulmonary disease (
30804561
)
Eosinophil percentage of white cells (
32888494
)
FEV1 (
30804560
)
Lung function (FEV1/FVC) (
30804560
)
Lymphocyte percentage of white cells (
27863252
)
Peak expiratory flow (
30804560
)
Systolic blood pressure (
29615537
)
Interacting Genes
240 interacting genes:
AARS2
ABL1
ACSL4
ADRB2
AGTR1
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ARHGEF2
ATP5F1A
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EGFR
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1
H2BC8
H4C14
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HSPB1
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
ITPRID2
KANK1
KCNK15
KCNK3
KCNK9
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SOCS3
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSX2IP
SUMO2
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRAF6
TRIM25
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBE2L3
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS1
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
160 interacting genes:
ABCA7
ADGRG1
ADRB3
AKAP12
AKAP5
ALDOA
ARF4
ARHGAP5
ARHGDIA
ARR3
ARRB1
ARRB2
ARRDC3
ARV1
ATP6V0B
ATP6V0D1
BACE1
BAZ2A
BSG
CAV3
CCKBR
CCND2
CD4
CD68
CD81
CD9
CEACAM1
CENPB
CLASP2
CLPTM1L
CNN1
CRYM
CSK
DCAF10
DCLRE1A
DNAJC14
DRD4
EGLN3
EIF2B1
FBXO17
GBP5
GJC2
GMPR2
GNA11
GNA14
GNA15
GNAI1
GNAI2
GNAS
GNAT2
GNB1
GNG2
GNL3L
GOLGB1
GPR37
GPRASP1
GPRC5B
GRB2
GRIA3
GRK1
GRK2
GRK3
GRK4
GRK5
GRK6
GTF2B
HDAC6
HNRNPK
HS2ST1
HTR4
IL1B
IL6R
INSR
KCNE1
KCNJ5
KCNJ6
KCNJ9
KCTD13
KLC1
LRATD2
MAPK8IP2
MBOAT2
MBP
MCAM
MDM2
MFSD12
MFSD2A
MGLL
MITF
MOG
MSR1
NAT14
NCOR2
NEDD4
NIPAL2
NOS1
NPTX1
OBP2A
OPRD1
PLA2G2D
PRDX1
PRKCD
PRNP
PTGDS
PTGER1
PTGES2
RAB14
RAB27A
RAB3A
RACK1
RAN
RAP2C
REL
RGR
RGS10
RGS11
RGS17
RGS2
RGS20
RGS5
RGS8
RGS9
RHOD
RIOX1
RNF41
RTN1
SACS
SENP3
SI
SLC37A1
SLC39A4
SLC52A2
SLC9A3R1
SLC9A3R2
SNCA
SNCG
SPTBN2
SRC
STAT3
STAT4
TCTA
TMCC2
TMEM144
TMEM187
TMEM259
TPTE
TSG101
TSHR
TSPAN7
UCHL1
UST
VAPA
VDAC1
VDAC2
VEGFB
WNK1
YIPF5
YWHAQ
ZNF25
ZNF254
Entrez ID
10971
154
HPRD ID
00886
00187
Ensembl ID
ENSG00000134308
ENSG00000169252
Uniprot IDs
P27348
P07550
X5DQM5
PDB IDs
2BTP
5IQP
6BCR
6BD2
6BQT
6KZG
6KZH
1GQ4
2R4R
2R4S
2RH1
3D4S
3KJ6
3NY8
3NY9
3NYA
3P0G
3PDS
3SN6
4GBR
4LDE
4LDL
4LDO
4QKX
5D5A
5D5B
5D6L
5JQH
5X7D
6E67
6KR8
6MXT
6N48
6NI3
6OBA
6PRZ
6PS0
6PS1
6PS2
6PS3
6PS4
6PS5
6PS6
7BZ2
Enriched GO Terms of Interacting Partners
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